15GEN3 Pleural f425803e 0088 8351 c497 1abf72481e1f

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General Cytopathology 15GEN3 Specimen: Pleural fluid Clinical Notes: Male 76 years. Recurrent right sided pleural effusion. Occupational asbestos exposure. CT shows right pleural plaques. Expected Response: Mesothelioma.

Figure 1. Low power view showing a cellular smear with many, large groups of cells with scalloped borders (DQ).

Figure 2. There are numerous large tubulo-papillary groups with scalloped edges (Pap).

Figure 3. Cell in cell arrangement seen in some groups (Pap).

Figure 4. Cells in large groups showing mesothelial features. Nuclei are oval to round and centrally placed (DQ).

Figure 5. Abnormal mesothelial cells are binucleated with dense, central but peripherally vacuolated cytoplasm with some metachromatically staining collagen balls. (DQ).

Figure 6. Cells in large group showing mesothelial features and oval round centrally placed nuclei with prominent single nucleoli (Pap).