15GEN6 Pleural fluid 36fdf053 7dc8 4ac1 f784 74739b4cd7b6

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General Cytopathology 15GEN6 Specimen: Pleural Fluid Clinical Notes: Male 71 years. Large right pleural effusion; dysphagia Expected Response: Adenocarcinoma

Figure 1. Highly cellular specimen with groups of abnormal cells in an inflammatory background (DQ).

Figure 3. Three dimensional cluster of malignant cells with large vacuoles that distend the cells and push the nuclei to the periphery. (Pap).

Figure 5. Sheets of abnormal cells with high N/C ratio and large hyperchromatic nuclei).

Figure 2. Malignant cells showing glandular differentiation with some large groups forming papillary-like arrangement (Pap).

Figure 4. Loose cluster of malignant cells with hypervacuolated cells. Two binucleated mesothelial cells are present among the background of histiocytes and polymorphs (DQ).

Figure 6. Nuclei are hyperchromatic with marginated chromatin. Some large bizarre cells show highly vacuolated cytoplasm (Pap).