Physical Properties: White powder (MP=156-159°C) MW=400.6
C27H44O2
Analysis: >98% (TLC); NMR (Conforms) Solubilization: May be dissolved in DMSO (30 mg/ml) Storage: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months. Pharmacology: Cholesterol metabolite. Endogenous agonist for nuclear receptor LXR1. Controls cellular cholesterol homeostasis2. Promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells3. Cell permeable. References: 1. A Chawla et al. Science 2001 294:1866 2. AJ Brown Int. J. Biochem. Cell Biol. 2009 41:744 3. S Theofilopoulos et al. Nature Chem. Biol. 2013 9:126
Not for human therapeutic use or for medicinal purposes. For research applications only.