biotechnology

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Image: Boehringer Ingelheim

SECTOR OVERVIEW

BIOTECHNOLOGY

BIOTECHNOLOGY

Biotechnology “Made in Baden-Württemberg” – a global player at the heart of Europe Baden-Württemberg’s location in the centre of Europe offers a significant advantage in that it guarantees access to many important markets. Biotech companies in Baden-Württemberg develop and produce high-quality technological products, making them leading players in Germany and Europe. Their biotech products enjoy high national and international demand and are used throughout the world.

Biotechnology in Germany



As biotechnology is a classic interface technology which has input not only from biology and biochemistry but also from physics, chemistry, process technology, material science and IT, the German biotech sector with its technologically advanced status in many of these individual disciplines, is at the forefront of all the German high-tech industries.



The biotech sector is made up of around 500 businesses in Germany with more than 15,000 employees who generate a turnover of over 2 billion Euros. If we include the ever increasing number of businesses which count biotechnology as part of their business, the following picture of the sector emerges: 600 businesses with around 30,000 employees generating a total turnover of more than 3 billion Euros.



In the field of biotechnology, Germany has become a driving force within Europe, with innovative, lucrative and marketable ideas.



Worldwide, German businesses hold the no. 2 position behind the USA in terms of annual patent applications in the field of biotechnology.



Germany„s strength within the fields of “red”, “green” and “white” biotechnology lies in particular in the “red” area, i.e. medical biotechnology. In this sector Germany holds the no. 1 position in Europe, and no. 2 in the world. Almost half



around 44% – of German biotech companies are specialists in the development of new medicines or diagnostic tests.

image: Boehringer Ingelheim

BIOTECHNOLOGY



Biotechnology in Baden-Württemberg

Around half of biotech companies in Baden-Württemberg focus on medical biotechnology. In this area, the companies and

Baden-Württemberg

is

one

of

the

leading

locations

research institutes of the south-west hold a dominant position in

for

Germany and indeed in Europe.

biotechnology in Germany.





average innovation potential and a strong willingness to co-

of biotech businesses. Around 80 businesses have more than

operate.

2,000 employees and generate an annual turnover of around 200 million Euros.



The biotech sector in Baden-Württemberg is marked by above-

Baden-Württemberg lies in second place in terms of the number



This geographical location has a high cluster of pharmaceutical companies and services and therefore guarantees ideal

As in the rest of Germany, businesses in Baden-Württemberg are

conditions for research and marketing, as well as the

mostly small businesses. Around 45% of these employ less than

manufacture of biotech products.

ten people, and a further 45% have up to 50 employees.

Baden-Württemberg leads in the field of biotechnology in Germany

Turnover

Employees

Turnover per employee (K EUR)

BW

Percentage BadenWürttemberg in Germany

Source: www.Biotechnology.de

Percentage BadenWürttemberg in Germany

D

Businesses

88.7

124.3

Percentage BadenWürttemberg in Germany

BIOTECHNOLOGY The university network in guarantees a large pool employees

Baden-Württemberg of highly-qualified



Image: Boehringer Ingelheim

High employee potential in biotechnology due to excellent higher education establishments At the nine universities and 23 higher education establishments in the state, approximately one third of students follow courses related to biotechnology. This places Baden-Württemberg above the German average.



Measured against the whole of Germany, around 16% of students in

courses

related

to

biotechnology

graduate

in

Baden-

Württemberg.



Biotechnology of Sewerage at the University of Karlsruhe, the Centre Systems Biology (CSB) at the University of Stuttgart, the

Baden-Württemberg has an excellent range of higher education

Life Science Center at the University of Hohenheim and the

establishments. At a total of eight universities in the south-west

Centre for Bioinformatics Tübingen (ZBIT) at the University of

there are special facilities and centres which have specialised

Tübingen.

particularly in various biotech disciplines in both teaching and research. These include the Institute for Microsystem Technology



The institutions specialising in medical technology at Heidelberg,

(IMTEK) at the University of Freiburg, the Institute for Pharmacy

Karlsruhe, Stuttgart and Freiburg in particular guarantee a

and Molecular Biotechnology (IPMB) at the University of

highly-qualified potential workforce and a high intensity of

Heidelberg, the Institute for Biological Engineering and the

research in the areas of medical and bio-technology.

Potential employees in biotechnology in Baden-Württemberg Graduates in disciplines related to biotechnology

Students in disciplines related to biotechnology

Baden-Württemberg

Baden-Württemberg

Germany

Germany

Baden-Württemberg

Germany

Precentage Baden-Württemberg in Germany

Students

72 972

505 026

14%

Graduates

10 613

66 607

16%

* Disciplines related to biotechnology (biotech): IT, physics, chemistry, biology, general health sciences, human medicine, general engineering, mechanical engineering/process engineering Source: German Office of Statistics

BIOTECHNOLOGY Research and development in biotechnology in Baden-Württemberg

Major research facilities

1

Helmholtz-Gemeinschaft e.V. Research centres

1

Max-Planck Institutes

6

Fraunhofer Institutes

4

Contract research facilities

1

Mannheim Heidelberg Heilbronn

Karlsruhe Pfinztal

46

University research faciltities Higher educational establishment research institutes

9

Federal research institutes

4 1

Other research facilities

Aalen

Stuttgart Denkendorf Offenburg

Tübingen/ Reutlingen

Ulm

Albstadt-Sigmaringen Furtwangen

Symbol stands for an institute/specialist area/centre

Freiburg Biberach

Constance

Baden-Württemberg – an excellent location for research and development The biotech sector in Baden-Württemberg is supported by a



high-performance, multi-faceted research network

and technical faculties, a multitude of major clinics and its proximity to numerous medical technology and pharmaceuticals

•At eight universities, nine specialist higher education establishments

companies, Baden-Württemberg offers an outstanding location

and 16 non-university research centres, scientists carry out biotech research at the highest level. These include internationally renowned facilities such as the German Cancer Research Centre and the European Laboratory for Molecular Biology in Heidelberg, as well as the Max-Planck Institute for Developmental Biology in Tübingen. I N N O V A T I O N S

F R O M

Due to its outstanding research infrastructure, renowned medical

for biotech companies.



Baden-Württemberg‟s infrastructure is one of the best in Europe. This is underpinned by a multitude of technology parks. There are bioparks in Freiburg, Heidelberg, Reutlingen/Tübingen, Esslingen and Ulm.

B A D E N - W Ü R T T E M B E R G

Research on fish The Institute for Toxicology and Genetics (ITG) in the Karlsruhe Institute for Technology (KIT), houses Europe„s largest centre for the analysis of key molecules in development and regeneration processes on the embryos of small freshwater fish. The centre contains more than 8,000 aquariums. The long-term goal of the research work is to develop biotech procedures and new therapeutic approaches to human diseases. The Karlsruhe Institute for Technology (KIT) is a facility carrying out outstanding international Photo source: Research centre Karlsruhe/Karlsruhe Institute for Technology

research and teaching in the biological sciences and engineering, employing a total of 8,000 people.

BIOTECHNOLOGY Those who network are more successful - BadenWürttemberg’s biotechnology networks strengthen the

innovative

capacity

and

international

The dense network of organisations with competency in the field of biotechnology in BadenWürttemberg

competitiveness of businesses. A multitude of active co-operation projects in biotechnology which cross company and institution boundaries stimulate Heidelberg

innovation, strengthen synergies and create new market potential for businesses based here.



14 active cluster initiatives and sector networks make a valuable and important contribution to expanding the leading position held by Baden-Württemberg.



Stuttgart

Five strong bio-regions have developed in Baden-Württemberg, more than in any other German state: the bio-region RhineReutlingen

Neckar-triangle in Heidelberg, the bio-region STERN in Stuttgart,

Ulm

the bio-region Freiburg, the bio-region Ulm and BioLAGO in Constance. These bio-regions within Baden-Württemberg are focussed on particularly forward-looking application fields within the area of biotechnology, and support the successful use of Freiburg

biotechnology in the south-west.



One particular advantage of the bio-regions is that to a significant extent private capital can be raised in them to enable biotech companies to expand. This capital-raising effect can be seen, for

Constance

example, in the bio-region Rhine-Neckar-triangle where it stands at over one thousand percent.





Strong networks also contribute to the optimum national and

targeted

international positioning, and the future-orientated development of

promotional measures. This secures know-how and jobs in the

Baden-Württemberg as a biotech centre.

state and enables the optimal transfer of the potential of

The BIOPRO network in Baden-Württemberg, in its function as a

way

through

specifically

arranged

commercial

innovative research into the economy.

state-wide active innovation company, supports research facilities and companies in the biotechnology and life sciences sector in a I N N O V A T I O N S

F R O M

B A D E N - W Ü R T T E M B E R G

Parasites in the genome Scientists as the Max-Planck Institute for Developmental Biology in Tübingen have deciphered the structure of a protein (L1ORF1p) which is coded by a parasitic genetic element and is essential for its mobility. This makes new knowledge about the relationships between retrotransposons and retroviruses possible, and probably also about evolutionary processes in humans and animals. One further success of this discovery could be that via the mechanism of the LINE-1 retrotransposon, genetic information could be smuggled into a person„s genetic make-up in a targeted way in future. This would be an alternative to less specifically targeted methods based on a retroviral mechanism. The Max-Planck Institute for Developmental Photo: Elena Khazina and Oliver Weichenrieder, Source: MPI for developmental biology

Biology carries out fundamental research in the areas of biochemistry, molecular biology, genetics and cell and evolutionary biology. It employs around 325 people and is based at the Max-Planck campus in Tübingen.

BIOTECHNOLOGY I N N O V A T I O N S

F R O M

B A D E N - W Ü R T T E M B E R G

Source: German Cancer Research Centre

Peptide Chips for better cancer diagnosis Synthetically manufactured short protein pieces, known as peptides, are an important tool for researchers and doctors. However, they are expensive and time-consuming to manufacture. Scientists in the German Cancer Research Centre (DKFZ) have succeeded in building peptides on a microchip. This new technique is extremely effective, as well as quicker and therefore cheaper than previous methods. This innovative technology has already received a science prize from the Foundation for German Science and will be series-manufactured by PEPperPRINT GmbH, a company set up by scientists from the DKFZ. The German Cancer Research Centre is the largest biomedical research facility in Germany and a member of the Helmholtz Association of German Research Centres. Over 2,000 employees, including 850 scientists, research the mechanisms by which cancer arises, and work on understanding cancer risk factors. They provide the basis for the development of new approaches in prevention, diagnosis and treatment of cancer diseases.

Baden-Württemberg – a trade fair centre

Baden-Württemberg companies active in the biotechnology sector:

Baden-Württemberg is one of the most dynamic trade fair locations in Germany. The federal state’s nine trade fair centres

4base lab GmbH │ Affimed Therapeutics AG │ AGRANO

have established Baden-Württemberg as a central market

GmbH & Co. KG │ AlbuPharm GmbH & Co. KG │ ALTANA

platform and are characterised by their excellent innovative and

Pharma AG │ AnDiaTec GmbH & Co. KG │ ATG:

multifunctional hall and area designs.

biosynthetics │ BERTHOLD TECHNOLOGIES GmbH & Co. KG │ BILATEC AG │ BioGeneriX AG │ BioTek European





For businesses in the field of biotechnology, Baden-Württemberg

Coordination Center │ BioTissue Technologies GmbH │

has proved to be an attractive destination for exhibitions and has

Boehringer Ingelheim Pharma GmbH & Co. KG │ CellGenix

hosted nationally and internationally important trade fairs and

Technologie Transfer GmbH │ DIARECT AG │ EML

conferences.

RESEARCH gGmbH Villa Bosch │ GATC Biotech AG │ Gene Architects AG │ Heidelberg Pharma AG │ Hölle &

The forward-looking range of topics covered by the various trade

Hüttner AG │ Insilico Biotechnology AG │ Merckle Biotec

fair concepts open up a unique opportunity for biotech businesses

GmbH │ MicroMol GmbH + FPQS │ OSSACUR AG │

to receive comprehensive information on the current range of

Promega

products and services offered in the area of development and

Biotechnologie GmbH │ Retina Implant GmbH │ STRATEC

manufacture, as well as to present themselves and their products

Biomedical Systems AG │ SYGNIS Pharma AG │ TETEC AG

GmbH



Promega

GmbH



Rentschler

at internationally renowned trade fairs.

Trade Fairs in the field of biotechnology in Baden-Württemberg

• Medipart, Specialist trade fair for precision metal components, assemblies and parts for the medical technology industry, Messe Karlsruhe

• MEDIZIN Specialist trade fair and conference, Neue Messe Stuttgart • MEDTEC Specialist trade fair and conference – components, materials, sub-contractor services and equipment for the medical equipment manufacturing industry in Europe, Neue Messe Stuttgart

• PREVENTIKA Trade fair and specialist conference for health and preventative medicine, Messe Karlsruhe

• REINRAUMLOUNGE, Messe Karlsruhe • TopClinica Medical equipment and solutions, Neue Messe Stuttgart

Further information on research establishments and networks available on request. Please contact us at:

[email protected]

Baden-Württemberg International Agency for International Economics and Scientific Cooperation Willi-Bleicher-Str. 19 | 70174 Stuttgart Germany Phone: +49 (0)711.22787-0 Fax: +49 (0)711.22787-22 E-Mail: [email protected] Internet: www.bw-i.de www.bw-invest.de