CD34818 lot 110 Vendor COA

CERTIFICATE OF ANALYSIS Product Name:

[13C,2H3]-Doxorubicin trifluoroacetate salt

Unlabeled Molecular Formula:

C27H29NO11 . CF3CO2H

Labeled Molecular Formula:

C2613CH26D3NO11 . CF3CO2H

Molecular Weight:

661.55 g/mol

Structure:

Batch Number:

ALG-ALS-15-110-P8

Product Number:

C2451

CAS Number:

23214-92-8 unlabeled free base

Storage:

For a prolonged period, keep at -20°C (±5°C) in a closed container, away from light and moisture

Stability:

Stable (24 months) (*)

Extended Expiring date:

Thursday January 18, 2018

Solvent solubility:

Soluble in Methanol or Water Specification:

Results:

Appearance:

Deep red solid

Deep red solid

Chemical Purity (HPLC-MS): Isotopic Enrichment:

≥ 95,0% ≥ 99% 13C, 98% 2H

98.0% 99.2% 13C, 99.8% 2H

Unlabeled (M+0) Content:

Unlabeled (M+0) content < 0.5%

0.0%

1H NMR:

Conform to structure

Conforms

13C NMR:

Conform to structure

Conforms

Mass Spectrometry:

Conform to structure

Conforms

Manufacturing date:

Thursday June 4, 2015

Reanalysis date:

Monday January 18, 2016

Analytical Review & Approval Toufik FELLAGUE, PhD Date: Monday January 18, 2016

Quality Review & Approval Jean-François HOEFFLER, PhD Date: Monday January 18, 2016

(*) This Certificate of Analysis is valid provided that the advised storage conditions were respected. Alsachim, Strasbourg - FRANCE, Certificate of analysis

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Alsachim, Strasbourg - FRANCE, Certificate of analysis

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Alsachim, Strasbourg - FRANCE, Certificate of analysis

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Alsachim, Strasbourg - FRANCE, Certificate of analysis

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Alsachim, Strasbourg - FRANCE, Certificate of analysis

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