Chapter 12: Aging â Related Memory Disorders
Chapter 12: Aging – Related Memory Disorders --- Alzheimer’s Disease
From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.
Chapter 12: Amyloid Plaques and Neurofibrillary Tangles
Amyloid Plaques and Neurofibrillary Tangles, AD
Figure 1
Stages of Neurofibrillary Pathology in Alzheimer’s Disease
Figure 2
Key Molecules Involved in Alzheimer’s Disease Pathogenesis
Figure 3
Tau Phoshorylation Sites
Figure 4
Fragment of Amyloid Beta Peptide
A
B C Terminus
N Terminus Figure 5
Amyloid Precursor Protein (APP)
g
Figure 6
APP, A, and the Secretases
Figure 7
PS1 A246 E FAD Mutant Transgene Accelerates Amyloid Plaque Pathology of Tg2576 Mice Tg 2576
Figure 8
Tg 2576 + PS1 A246E
Effect of apoE Genotype on AD Risk
Figure 9
Reelin and ApoE Signaling --- Implications for AD
Figure 10
FEAR CONDITIONING Training percent freezing
100
Wild Type n=9 PS-1 M146L n=6 APP K670N, M671L n=9 Double n=9
80 60 40 20 0 0
1
2
3
4
5
6
2 Pairings
7
Context
Cued 100
percent freezing
percent freezing
100 80 60 40 20 0
60 40 20 0
0
Figure 11
80
1
2
3
4
5
6
0
1
2
3
4
5
Microscopic Features of Alzheimer’s Disease
Blue Box 1
Cholinergic Hypothesis of Alzheimer's Disease and Current Pharmacotherapies A
B
Blue Box 2
From Wang et al. (2000) The Journal of Biological Chemistry 275: 5626-5632.
From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.
Chapter 12: Amyloid Plaques and Neurofibrillary Tangles
Amyloid Plaques and Neurofibrillary Tangles, AD
Figure 1
Stages of Neurofibrillary Pathology in Alzheimer’s Disease
Figure 2
Key Molecules Involved in Alzheimer’s Disease Pathogenesis
Figure 3
Tau Phoshorylation Sites
Figure 4
Fragment of Amyloid Beta Peptide
A
B C Terminus
N Terminus Figure 5
Amyloid Precursor Protein (APP)
g
Figure 6
APP, A, and the Secretases
Figure 7
PS1 A246 E FAD Mutant Transgene Accelerates Amyloid Plaque Pathology of Tg2576 Mice Tg 2576
Figure 8
Tg 2576 + PS1 A246E
Effect of apoE Genotype on AD Risk
Figure 9
Reelin and ApoE Signaling --- Implications for AD
Figure 10
FEAR CONDITIONING Training percent freezing
100
Wild Type n=9 PS-1 M146L n=6 APP K670N, M671L n=9 Double n=9
80 60 40 20 0 0
1
2
3
4
5
6
2 Pairings
7
Context
Cued 100
percent freezing
percent freezing
100 80 60 40 20 0
60 40 20 0
0
Figure 11
80
1
2
3
4
5
6
0
1
2
3
4
5
Microscopic Features of Alzheimer’s Disease
Blue Box 1
Cholinergic Hypothesis of Alzheimer's Disease and Current Pharmacotherapies A
B
Blue Box 2
From Wang et al. (2000) The Journal of Biological Chemistry 275: 5626-5632.
