Figure S5

Figure S5 B

scaffolds

scaffolds per bin

PGM-KD coverage

A

scaffold length (bp)

% GC

C

IES

IES MDS

MDS

OES

OES

OES

E

OES retention (%)

PGM-KD

NOWA1/2-KD

EZL1-KD

DCL2/3-KD

PTCAF1-KD

PDSG2-KD

DCL2/3/5-KD

DCL5-KD

TFIIS4-KD

100 Percentage

D Knockdown

MDS

No alternative excision detected Alternative excision detected

10

1

0.1

0.01

0.001 OES length (bp)

IES length (bp)