Formulation Development
Formulation Development
M-110P Microfluidizer Processor Ref. www.microfluidicscorp.com
Introduction • A Microfluidizer is a high shear fluid processor that relies upon the forces of shear, impact, and cavitation • The applications of the equipment: • Emulsification of multiple immiscible liquids • Deagglomeration of solid particles in a liquid media • Particle/droplet size reduction • Processing benefits of using a Microfluidizer processor: • Small particle/droplet size (often sub-micron) • Uniform particle/droplet size distributions (small polydispersity index) • Ability to process continuously • Small holdup volume (< 20 mL) allows screening of multiple formulations quickly
Applications Formulation Types • Encapsulation • Emulsions • Liposomes • Polymers • Suspensions • Deagglomeration • Cell lysis
Pharmaceutical Delivery • Parenteral • Oral • Ophthalmic • Topical • Inhalable • Controlled Release • Vaccine adjuvants
Nanoencapsulation Nanoencapsulation: Nanoparticles or droplets surrounded by a coating or wall
• Protection of active material Fish oil and vitamin protected from oxidation
• Control delivery of the active ingredient Cancer drugs, vaccines, anti-corrosion agents
• Masking of taste or odor Flavor microcapsules for drugs, fish oil
The M-110P offers three platforms for nanoencapsulation Nanoemulsions – Liposomes – Polymers
High Pressure Homogenization HPH: Milling solids within a liquid media to reduce size or lyse cells
• Reduce particle size / deagglomeration Increase surface to volume ratio for improved efficacy
• Control efficacy of the active ingredient Small polydispersity provides more reproducible outcomes
• Lyse cell membranes Release valuable intracellular components
High pressure homogenization, using the M-110P, benefits several types of applications
M-110P Microfluidizer Processor Ref. www.microfluidicscorp.com
Introduction • A Microfluidizer is a high shear fluid processor that relies upon the forces of shear, impact, and cavitation • The applications of the equipment: • Emulsification of multiple immiscible liquids • Deagglomeration of solid particles in a liquid media • Particle/droplet size reduction • Processing benefits of using a Microfluidizer processor: • Small particle/droplet size (often sub-micron) • Uniform particle/droplet size distributions (small polydispersity index) • Ability to process continuously • Small holdup volume (< 20 mL) allows screening of multiple formulations quickly
Applications Formulation Types • Encapsulation • Emulsions • Liposomes • Polymers • Suspensions • Deagglomeration • Cell lysis
Pharmaceutical Delivery • Parenteral • Oral • Ophthalmic • Topical • Inhalable • Controlled Release • Vaccine adjuvants
Nanoencapsulation Nanoencapsulation: Nanoparticles or droplets surrounded by a coating or wall
• Protection of active material Fish oil and vitamin protected from oxidation
• Control delivery of the active ingredient Cancer drugs, vaccines, anti-corrosion agents
• Masking of taste or odor Flavor microcapsules for drugs, fish oil
The M-110P offers three platforms for nanoencapsulation Nanoemulsions – Liposomes – Polymers
High Pressure Homogenization HPH: Milling solids within a liquid media to reduce size or lyse cells
• Reduce particle size / deagglomeration Increase surface to volume ratio for improved efficacy
• Control efficacy of the active ingredient Small polydispersity provides more reproducible outcomes
• Lyse cell membranes Release valuable intracellular components
High pressure homogenization, using the M-110P, benefits several types of applications
