Jiaqi Lan - Northeastern University
Graduate Category: Engineering and Technology Degree Level: PhD Abstract ID# 524
Comparative Toxicity Assessment of Various Disinfection Processes Using Quantitative Toxicogenomics Analysis Man
Ai
2 Jia ;
Na
1 Gou ;
Jiaqi
1 Lan ;
Shane A.
2 Snyder ;
April Z.
1 Gu
of Civil and Environmental Engineering, Northeastern University, Boston, MA 02115; 2Department of Chemical and Environmental Engineering, University of Arizona, Tucson, AZ 85721
In this study, we applied a novel stress gene-based toxicogenomics approach, using GFP-fused E. coli reporter cell library, to evaluate the mechanistic toxicity of municipal wastewater effluents disinfected by different technologies, including chlorination(Cl2), chloramination(NH2Cl), ozonation(O3), UV as well as combination of UV and H2O2.
Current water toxicity assessments mostly rely on in vivo whole animal-based tests, which are resource-intensive, time-consuming and thus hard to meet the testing demands of the large number of environment samples. The toxicogenomics-based toxicity assessment method developed by us allows a simple, fast but informative, mechanistic and quantitative toxicity evaluation of pollutants. The objective of this study is to apply this toxicogenomics assay to compare toxicity level and nature of disinfected effluents in response to different disinfection processes.
The toxicogenomics-based molecular toxicity assay was more sensitive than MicroTox assay. The results showed that compared with raw effluents, samples disinfected by NH2Cl demonstrated a remarkable increase in the overall toxicity. In addition, effluents treated with UV (p
Comparative Toxicity Assessment of Various Disinfection Processes Using Quantitative Toxicogenomics Analysis Man
Ai
2 Jia ;
Na
1 Gou ;
Jiaqi
1 Lan ;
Shane A.
2 Snyder ;
April Z.
1 Gu
of Civil and Environmental Engineering, Northeastern University, Boston, MA 02115; 2Department of Chemical and Environmental Engineering, University of Arizona, Tucson, AZ 85721
In this study, we applied a novel stress gene-based toxicogenomics approach, using GFP-fused E. coli reporter cell library, to evaluate the mechanistic toxicity of municipal wastewater effluents disinfected by different technologies, including chlorination(Cl2), chloramination(NH2Cl), ozonation(O3), UV as well as combination of UV and H2O2.
Current water toxicity assessments mostly rely on in vivo whole animal-based tests, which are resource-intensive, time-consuming and thus hard to meet the testing demands of the large number of environment samples. The toxicogenomics-based toxicity assessment method developed by us allows a simple, fast but informative, mechanistic and quantitative toxicity evaluation of pollutants. The objective of this study is to apply this toxicogenomics assay to compare toxicity level and nature of disinfected effluents in response to different disinfection processes.
The toxicogenomics-based molecular toxicity assay was more sensitive than MicroTox assay. The results showed that compared with raw effluents, samples disinfected by NH2Cl demonstrated a remarkable increase in the overall toxicity. In addition, effluents treated with UV (p
