keynote
APRIL 27, 2010 • NORMANDY FARM • BLUE BELL, PA
KEYNOTE Gregory Verdine, Ph.D.
Departments of Stem Cell and Regenerative Biology, Chemistry and Chemical Biology, and Molecular and Cellular Biology, Harvard University and Chemical Biology Initiative and Program in Cancer Chemical Biology, Dana-Farber Cancer Institute
BIOGRAPHY: Professor Gregory L. Verdine’s research interests lie in the
emerging area of chemical biology. He and his co-workers study biologic processes underlying control of gene expression and preservation of genomic integrity. He has made major contributions to the understanding of DNA damage recognition and repair by base-excision DNA repair enzymes. He has also pioneered new and powerful approaches for the discovery of unconventional bioactive ligands for receptors that have proven difficult to target with conventional drugs. Professor Verdine received his B.S. degree in 1982 from St. Joseph’s University and his Ph.D. in 1986 from Columbia University (under Koji Nakanishi and Maria Tomasz). Following an NIH postdoctoral fellowship with Chris Walsh at M.I.T. and Harvard Medical School, he joined the Harvard University Department of Chemistry in 1988. Verdine was promoted to Full Professor in 1994 and was also named Harvard College Professor in 2000. In 2002, he was named the Erving Professor of Chemistry, the longest-established endowed professorship at Harvard. He is a Full Member of the Harvard Department of Molecular and Cellular Biology, and co-directs two graduate programs, the University-wide Graduate Program in Chemical Biology (co-founded with Jon Clardy) and the Graduate Program in Molecular, Cellular and Chemical Biology. Together with Stanley J. Korsmeyer, Verdine co-founded the Harvard/Dana-Farber Program in Cancer Chemical Biology and was named its first Executive Director; he also serves as the Executive Director of the Dana-Farber Chemical Biology Initiative. He has published more than 150 original research articles. Verdine has received numerous awards and honors, including the National Science Foundation Presidential Young Investigator Award, the Sloan Fellowship, the Searle Scholar Award, the Eli Lilly Award in Biological Chemistry, the Arthur C. Cope Scholar Award, the Nucleic Acids Award of the Royal Society of Chemistry, the Cruikshank Award of the Gordon Research Conferences, and the Nobel Laureate Signature Award of the American Chemical Society (with Anirban Banerjee). He currently serves as Founder and Chair of the Scientific Advisory Boards of Enanta Pharmaceuticals, Aileron Therapeutics, and Gloucester Pharmaceuticals, and is a Special Advisor to the Texas Pacific Group.
Staples and Proteins ABSTRACT: One of the most vexing problems in life science is that of “undruggability,” the difficulty of targeting certain biological macromolecules in vivo using existing drug or ligand discovery technologies. It has been estimated that as many as 80-90% of all potential targets, including many that have been extensively validated in humans and in animal models, are undruggable. Among the most biologically validated and yet chemically intractable of all targets are transcription factors, master regulatory proteins that are inappropriately activated in a large percentage of human tumors. The Verdine laboratory is developing powerful new chemistry-based platform technologies to address undruggable targets, including transcription factors. Specifically, the lab is developing “synthetic biologics,” molecules that, like biologics, possess the ability to target large flat surfaces, but that, like small molecules, are fully synthetic and hence can be modified at will. Progress on the development of one class of synthetic biologics – hydrocarbon-stapled alphahelical peptides – for use in targeting transcription factors will be reviewed in this talk.
PROGRAM
Scientific Symposium April 27, 2010
9:00 AM - 9:10 AM
“Welcome”
Ronnye Schreiber President, PlanetConnect & Ron Wegrzyn Associate Director, GlaxoSmithKline
9:10 AM - 10:00 AM
“Staples and Proteins”
Greg Verdine, Ph.D. Departments of Stem Cell and Regenerative Biology, Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University and Chemical Biology Initiative and Program in Cancer Chemical Biology, Dana-Farber Cancer Institute
10:00 AM - 10:30 AM
“Immune Engineering”
Michel Sadelain, MD, Ph.D. Director, Gene Transfer and Somatic Cell Engineering Facility Stephen and Barbara Friedman Chair Memorial Sloan-Kettering Cancer Center
10:30 AM - 11:00 AM
Break/ Visit Exhibitors: Arctic White, Blue Sky Biotech, Cambridge Research Biochemicals, CEM, Gene Pathway, GENEWIZ, Harvard Apparatus, JULABO, Li-Cor Biosciences, PromoCell, SDIX, STEMCELL Technologies, TTP LabTech, Zen-Bio 11:00 AM - 11:30 AM
“siRNA and Cancer Stem Cells”
Fabio Petrocca, MD Research Fellow Immune Disease Institute Harvard Medical School
11:30 AM - 12:00 PM
“Epigenetics and Cancer”
Fabrice Roegiers, Ph.D. Assistant Professor and Co-Leader Keystone Program in Epigenetics and Progenitor Cells Fox Chase Cancer Center
12:00 PM - 1:00 PM
Lunch/ Visit Exhibitors: Arctic White, Blue Sky Biotech, Cambridge Research Biochemicals, CEM, Gene Pathway, GENEWIZ, Harvard Apparatus, JULABO, Li-Cor Biosciences, PromoCell, SDIX, STEMCELL Technologies, TTP LabTech, Zen-Bio
PROGRAM
Scientific Symposium April 27, 2010
1:00 PM - 1:30 PM
“Cancer Stem Cells and Markers”
Steven McMahon, Ph.D. Department of Cancer Biology, Kimmel Cancer Center Associate Professor, Jefferson Medical College
1:30 PM - 2:00 PM
“Immunotherapy for Cancer”
Carmine Carpenito, MD Robert H. Vonderheide & The Translational Research Program University of Pennsylvania
2:00 PM - 2:30 PM
“Self-cannabilism and Survival of Quiescent Fibroblasts”
Hilary Coller, Ph.D. Assistant Professor Department of Molecular Biology Princeton University
2:30 PM - 3:00 PM
Break/ Visit Exhibitors: Arctic White, Blue Sky Biotech, Cambridge Research Biochemicals, CEM,
Gene Pathway, GENEWIZ, Harvard Apparatus, JULABO, Li-Cor Biosciences, PromoCell, SDIX, STEMCELL Technologies, TTP LabTech, Zen-Bio 3:00 PM - 3:30 PM
“Tumor Specific Oncolytic Measles Viruses”
Kah Whye Peng, Ph.D. Professor Director of the Molecular Medicine Toxicology/Pharmacology Laboratory, Mayo Clinic
3:30 PM - 4:00 PM “Coupling Somatic Hypermutation with Mammalian Cell Display for Antibody Discovery & Optimization”
David King, Ph.D. Vice President Research AnaptysBio
Scientific Symposium April 27, 2010
EXHIBITORS
Arctic White www.arcticwhiteusa.com 610-442-3207
ArcticWhite offers a family of products for laboratory efforts in high throughput screening, compound storage, compound management, ADMET, drug metabolism, pharmacokinetics, high throughput synthesis, targeted compound synthesis, combinatorial chemistry, drug discovery, PCR, and gene expression. Products include 24 well to 1536 well plates, pipette tips, dry down stations, storage tube and vial sorters, heat sealers, constant temperature thermal blocks, custom coating for both cell based and enzyme based assays, and the ArctiSeal™ brand of sealing mat closures.
take scientists away from key experimentation, novel theory exploration and other optimal uses of their time. Blue Sky is synonymous with productivity in the early discovery biology processes known as genetic cloning, recombinant protein expression and laboratoryscale fermentation (scale-up bioprocessing), as well as offering a wide variety of Products. Blue Sky is motivated by its ability to impact the overall efficiency of the drug discovery process, thus contributing to a longer, healthier lifespan for human beings.
Cambridge Research Biochemicals www.crbdiscovery.com +44(0)1642-567-180
Cambridge Research Biochemicals is a world leader in peptide synthesis and custom antibody production. Blue Sky Biotech www.blueskybiotech.com (800) 383-7795
Blue Sky Biotech, Inc. is a Contract Research Organization (CRO) in the pharmaceutical R&D market. As a trusted partner to nine of Fortune’s Top 10 Pharmaceutical Companies, Blue Sky has a proven track record with industry leaders. Blue Sky aims to alleviate the onerous and labor-intensive tasks that
Our aim is simple: The highest quality service in custom-made peptides and antibodies. We provide researchers with exact solutions in fluorescence, peptides, antibodies and other biochemical products helping solve their exact questions. Our experience for 30 years in the field provides unparalleled expertise and excellence.
CEM www.cem.com 704-821-7015
CEM is a leading global provider of microwave laboratory systems for proteomics applications, peptide synthesis, and chemical synthesis. The Discover® Proteomics System decreases sample prep time to minutes and improves efficiencies. Perform enzymatic in-gel or solution digests, ICAT and iTRAQ™ tagging, deglycosylations, residue-specific acid cleavages, and membrane protein solubilizations in minutes with better results than conventional methods. Make your own high purity peptides faster than conventional methods. Our Liberty and Liberty1 automated microwave peptide synthesizers are used by prestigious research institutes and major pharmaceutical and biotech companies around the world. For over 30 years, more scientists have trusted CEM for innovative, dependable microwave laboratory systems than any other company.
EXHIBITORS Genpathway Genpathway www.genpathway.com (858) 457-3250
Comprehensive chromatin and methylated DNA immunoprecipitation (ChIP) assay and data analysis services for the discovery and identification of gene regulated events and pathways by studying transcription factor binding, gene transcription, and epigenetic events such as DNA methylation and histone modification.
Scientific Symposium April 27, 2010 mutagenesis, and shRNA plasmid construction. GENEWIZ Genomic Services: Fragment analysis, mutation analysis, and SNP discovery sequencing. Highly experienced with custom projects.
Julabo www.julabo.com (610) 231-0250
GENEWIZ www.genewiz.com (908) 222-0711
GENEWIZ is the trusted provider of award-winning DNA sequencing, gene synthesis, and other molecular biology and genomic services. GENEWIZ DNA Sequencing Services: High-throughput sequencing of DNA, bacteria, and phage supernatant. Primer walking and best-in-class sequencing of hairpin, RNAi, and GC-rich difficult templates. GENEWIZ Molecular Biology Services: Gene synthesis, plasmid preparations, site-directed
Since 1967, JULABO has been recognized as a market leader and technological innovator in producing temperature control instruments. JULABO produces temperature regulating equipment that circulates a thermal fluid for applications ranging from -91 to +335 °C. The product line varies from instruments that heat only (to +335 °C) to highly dynamic instruments with a wide temperature capability (-91 to +250 °C) to chillers with up to 20 kW cooling power. JULABO offers a variety of instruments specific to many applications. Our customers span from the pharmaceutical, petroleum, and semi-conductor industries to food preparation, academic laboratories and many others. Over the last 42 years JULABO has continually introduced new technology in their products allowing for higher levels of performance without complicated operation.
®
Li-Cor Biosciences www.licor.com 402-467-3576
LI-COR® Biosciences is a leading manufacturer of near-infrared imaging systems and IRDye infrared dye reagents for various applications, including quantitative Western Blotting, cell-based assays, small animal imaging, microscopy, and DNA fragment analysis. The company also offers accessories and reagents for other detection applications. LI-COR pioneered the development of near-infrared fluorescence detection systems for DNA sequencing and today provides systems for drug discovery, protein research, small animal imaging, and undergraduate training. LI-COR instruments for photosynthesis, carbon dioxide analysis and light measurement are recognized worldwide for standard-setting innovation in plant science research and environmental monitoring.
EXHIBITORS PromoCell www.promocell.com (866) 251-2860
Since PromoCell was established in 1990 in Heidelberg, our company has always endeavoured to support the trend towards carrying out in-vitro cell culture tests using normal human primary cells. As a result of the regular contact between the staff of our research and development department and other scientists, we have been able to provide, at an early stage, relevant high quality cell types together with serum-free or low-serum cell culture media. This programme has been steadily expanded and supplemented, with regard to cell biology, by the range of important growth factors and antibodies. PromoCell is now a global operation, with a distribution network spread across many countries.
SDIX /www.sdix.com (302) 456-6789
SDIX is a biotechnology company, expert at creating advantage by providing a broad range of quality, innovative and effective immuno-solutions to the Pharmaceutical, Biotechnology, Diagnostics, and Food Safety markets. For
Scientific Symposium April 27, 2010 20 years, SDIX has developed antibodies which advance its customers’ immuno-based work reducing time, labor, and costs while increasing accuracy and reliability of results. SDIX offers a full suite of integrated immuno-solution capabilities including assay design, development, and production. In life science markets, SDIX capabilities are being used to help discover the mechanisms of disease, facilitate the development of new drugs, and provide mechanisms for rapid diagnosis. SDIX has also developed a unique Genomic Antibody Technology™ platform which is fastest and most cost effective method for generating Abs against conformational epitopes.
TTP LABTECH www.ttplabtech.com (617) 494-9794
TTP LabTech supplies custom automation and laboratory instrumentation for the healthcare, biotech and pharmaceutical sectors. Its products include: comPOUND® modular cherry-picking sample store; mosquito® nanolitre liquid handler; and Acumen Explorer® imaging cytometer for ultra high throughput, high content screening assays.
ZenBio Stemcell Technologies www.stemcell.com (604) 877-0713
STEMCELL Technologies is committed to supporting stem cell and many other areas of life science research worldwide by providing enabling research tools that are innovative, timely and of consistently high quality. STEMCELL’s specialized media and cell separation products are available for a wide range of research applications, and are complemented by a diverse array of cytokines, antibodies, tissue culture reagents, as well as services including contract assays, proficiency testing, and training.
www.zen-bio.com (919) 547-0692
Zen-Bio, Inc. (ZB) is a leading global provider of advanced cell-based solutions and services to the life science, cosmetics, and personal care communities. The company, founded in 1995, was a pioneer in adipose derived stem cells (ASCs) and continues this legacy providing cutting edge human primary cell culture products and services. Our mission is to provide the highest quality human cell systems, reagents and contract services to our research partners, to develop and commercialize innovative research tools, leverage our expertise through research and development and strategic alliances, and accelerate discovery.
NON-PROFIT SPONSORS
AWIS http://awis-cjc.org
Our Mission: To empower and promote scientists in the local community through education, networking, service, leadership, entrepreneurship
BioPharma Research Council
Pennsylvania Biotechnology Center www.pabiotechbc.org
Pennsylvania Biotech Center The Pennsylvania Biotechnology Center of Bucks County is the result of a unique partnership to create an historic and transformational force from which discoveries will be born, students will be trained, and new companies will be launched.
BioPharma Research Council www.biopharmaresearchcouncil.org
The BioPharma Research Council (BRC) is an independent, nonprofit corporation focused on the needs of the biopharmaceutical research community and its product and service suppliers. Our objective is to provide educational resources to the scientific community. We believe that scientific discourse and debate is central to the research and development process. Yet many organizations have slashed their travel and professional development budgets. We hope to fill the void left by budget cuts, and provide a local forum for scientists to meet and share ideas on a broad variety of topics affecting the BioPharma Industry.
Regional Biotech Council www.ihvr.org/rbc/
The mission of the Regional Biotech Council is to provide a stimulating networking environment and strategic support for biotech entrepreneurs within the five county region of Southeastern Pennsylvania - Chester, Montgomery, Delaware, Philadelphia and Bucks. The Regional Biotech Council is hosted by the Institute of Hepatitis and Virus Research, the research affiliate of the Hepatitis B Foundation, and funded in part by a grant from Ben Franklin Technology Partners of Southeastern Pennsylvania.
Scientific Symposium April 27, 2010
SYMPOSIUM PRODUCED & MANAGED BY:
ABOUT US PlanetConnect, Inc. is in the business of producing internal proprietary life science events for Merck, Johnson & Johnson, BMS and other large Pharma. We also host external multi-Pharma/Biotech events and user groups throughout the U.S. For information about additionally scheduled Scientific Symposia and Tradeshows, visit events.planetconnect.com. If you are interested in speaking or exhibiting at our next events, send email to [email protected] or call 732-933-9473.
KEYNOTE Gregory Verdine, Ph.D.
Departments of Stem Cell and Regenerative Biology, Chemistry and Chemical Biology, and Molecular and Cellular Biology, Harvard University and Chemical Biology Initiative and Program in Cancer Chemical Biology, Dana-Farber Cancer Institute
BIOGRAPHY: Professor Gregory L. Verdine’s research interests lie in the
emerging area of chemical biology. He and his co-workers study biologic processes underlying control of gene expression and preservation of genomic integrity. He has made major contributions to the understanding of DNA damage recognition and repair by base-excision DNA repair enzymes. He has also pioneered new and powerful approaches for the discovery of unconventional bioactive ligands for receptors that have proven difficult to target with conventional drugs. Professor Verdine received his B.S. degree in 1982 from St. Joseph’s University and his Ph.D. in 1986 from Columbia University (under Koji Nakanishi and Maria Tomasz). Following an NIH postdoctoral fellowship with Chris Walsh at M.I.T. and Harvard Medical School, he joined the Harvard University Department of Chemistry in 1988. Verdine was promoted to Full Professor in 1994 and was also named Harvard College Professor in 2000. In 2002, he was named the Erving Professor of Chemistry, the longest-established endowed professorship at Harvard. He is a Full Member of the Harvard Department of Molecular and Cellular Biology, and co-directs two graduate programs, the University-wide Graduate Program in Chemical Biology (co-founded with Jon Clardy) and the Graduate Program in Molecular, Cellular and Chemical Biology. Together with Stanley J. Korsmeyer, Verdine co-founded the Harvard/Dana-Farber Program in Cancer Chemical Biology and was named its first Executive Director; he also serves as the Executive Director of the Dana-Farber Chemical Biology Initiative. He has published more than 150 original research articles. Verdine has received numerous awards and honors, including the National Science Foundation Presidential Young Investigator Award, the Sloan Fellowship, the Searle Scholar Award, the Eli Lilly Award in Biological Chemistry, the Arthur C. Cope Scholar Award, the Nucleic Acids Award of the Royal Society of Chemistry, the Cruikshank Award of the Gordon Research Conferences, and the Nobel Laureate Signature Award of the American Chemical Society (with Anirban Banerjee). He currently serves as Founder and Chair of the Scientific Advisory Boards of Enanta Pharmaceuticals, Aileron Therapeutics, and Gloucester Pharmaceuticals, and is a Special Advisor to the Texas Pacific Group.
Staples and Proteins ABSTRACT: One of the most vexing problems in life science is that of “undruggability,” the difficulty of targeting certain biological macromolecules in vivo using existing drug or ligand discovery technologies. It has been estimated that as many as 80-90% of all potential targets, including many that have been extensively validated in humans and in animal models, are undruggable. Among the most biologically validated and yet chemically intractable of all targets are transcription factors, master regulatory proteins that are inappropriately activated in a large percentage of human tumors. The Verdine laboratory is developing powerful new chemistry-based platform technologies to address undruggable targets, including transcription factors. Specifically, the lab is developing “synthetic biologics,” molecules that, like biologics, possess the ability to target large flat surfaces, but that, like small molecules, are fully synthetic and hence can be modified at will. Progress on the development of one class of synthetic biologics – hydrocarbon-stapled alphahelical peptides – for use in targeting transcription factors will be reviewed in this talk.
PROGRAM
Scientific Symposium April 27, 2010
9:00 AM - 9:10 AM
“Welcome”
Ronnye Schreiber President, PlanetConnect & Ron Wegrzyn Associate Director, GlaxoSmithKline
9:10 AM - 10:00 AM
“Staples and Proteins”
Greg Verdine, Ph.D. Departments of Stem Cell and Regenerative Biology, Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University and Chemical Biology Initiative and Program in Cancer Chemical Biology, Dana-Farber Cancer Institute
10:00 AM - 10:30 AM
“Immune Engineering”
Michel Sadelain, MD, Ph.D. Director, Gene Transfer and Somatic Cell Engineering Facility Stephen and Barbara Friedman Chair Memorial Sloan-Kettering Cancer Center
10:30 AM - 11:00 AM
Break/ Visit Exhibitors: Arctic White, Blue Sky Biotech, Cambridge Research Biochemicals, CEM, Gene Pathway, GENEWIZ, Harvard Apparatus, JULABO, Li-Cor Biosciences, PromoCell, SDIX, STEMCELL Technologies, TTP LabTech, Zen-Bio 11:00 AM - 11:30 AM
“siRNA and Cancer Stem Cells”
Fabio Petrocca, MD Research Fellow Immune Disease Institute Harvard Medical School
11:30 AM - 12:00 PM
“Epigenetics and Cancer”
Fabrice Roegiers, Ph.D. Assistant Professor and Co-Leader Keystone Program in Epigenetics and Progenitor Cells Fox Chase Cancer Center
12:00 PM - 1:00 PM
Lunch/ Visit Exhibitors: Arctic White, Blue Sky Biotech, Cambridge Research Biochemicals, CEM, Gene Pathway, GENEWIZ, Harvard Apparatus, JULABO, Li-Cor Biosciences, PromoCell, SDIX, STEMCELL Technologies, TTP LabTech, Zen-Bio
PROGRAM
Scientific Symposium April 27, 2010
1:00 PM - 1:30 PM
“Cancer Stem Cells and Markers”
Steven McMahon, Ph.D. Department of Cancer Biology, Kimmel Cancer Center Associate Professor, Jefferson Medical College
1:30 PM - 2:00 PM
“Immunotherapy for Cancer”
Carmine Carpenito, MD Robert H. Vonderheide & The Translational Research Program University of Pennsylvania
2:00 PM - 2:30 PM
“Self-cannabilism and Survival of Quiescent Fibroblasts”
Hilary Coller, Ph.D. Assistant Professor Department of Molecular Biology Princeton University
2:30 PM - 3:00 PM
Break/ Visit Exhibitors: Arctic White, Blue Sky Biotech, Cambridge Research Biochemicals, CEM,
Gene Pathway, GENEWIZ, Harvard Apparatus, JULABO, Li-Cor Biosciences, PromoCell, SDIX, STEMCELL Technologies, TTP LabTech, Zen-Bio 3:00 PM - 3:30 PM
“Tumor Specific Oncolytic Measles Viruses”
Kah Whye Peng, Ph.D. Professor Director of the Molecular Medicine Toxicology/Pharmacology Laboratory, Mayo Clinic
3:30 PM - 4:00 PM “Coupling Somatic Hypermutation with Mammalian Cell Display for Antibody Discovery & Optimization”
David King, Ph.D. Vice President Research AnaptysBio
Scientific Symposium April 27, 2010
EXHIBITORS
Arctic White www.arcticwhiteusa.com 610-442-3207
ArcticWhite offers a family of products for laboratory efforts in high throughput screening, compound storage, compound management, ADMET, drug metabolism, pharmacokinetics, high throughput synthesis, targeted compound synthesis, combinatorial chemistry, drug discovery, PCR, and gene expression. Products include 24 well to 1536 well plates, pipette tips, dry down stations, storage tube and vial sorters, heat sealers, constant temperature thermal blocks, custom coating for both cell based and enzyme based assays, and the ArctiSeal™ brand of sealing mat closures.
take scientists away from key experimentation, novel theory exploration and other optimal uses of their time. Blue Sky is synonymous with productivity in the early discovery biology processes known as genetic cloning, recombinant protein expression and laboratoryscale fermentation (scale-up bioprocessing), as well as offering a wide variety of Products. Blue Sky is motivated by its ability to impact the overall efficiency of the drug discovery process, thus contributing to a longer, healthier lifespan for human beings.
Cambridge Research Biochemicals www.crbdiscovery.com +44(0)1642-567-180
Cambridge Research Biochemicals is a world leader in peptide synthesis and custom antibody production. Blue Sky Biotech www.blueskybiotech.com (800) 383-7795
Blue Sky Biotech, Inc. is a Contract Research Organization (CRO) in the pharmaceutical R&D market. As a trusted partner to nine of Fortune’s Top 10 Pharmaceutical Companies, Blue Sky has a proven track record with industry leaders. Blue Sky aims to alleviate the onerous and labor-intensive tasks that
Our aim is simple: The highest quality service in custom-made peptides and antibodies. We provide researchers with exact solutions in fluorescence, peptides, antibodies and other biochemical products helping solve their exact questions. Our experience for 30 years in the field provides unparalleled expertise and excellence.
CEM www.cem.com 704-821-7015
CEM is a leading global provider of microwave laboratory systems for proteomics applications, peptide synthesis, and chemical synthesis. The Discover® Proteomics System decreases sample prep time to minutes and improves efficiencies. Perform enzymatic in-gel or solution digests, ICAT and iTRAQ™ tagging, deglycosylations, residue-specific acid cleavages, and membrane protein solubilizations in minutes with better results than conventional methods. Make your own high purity peptides faster than conventional methods. Our Liberty and Liberty1 automated microwave peptide synthesizers are used by prestigious research institutes and major pharmaceutical and biotech companies around the world. For over 30 years, more scientists have trusted CEM for innovative, dependable microwave laboratory systems than any other company.
EXHIBITORS Genpathway Genpathway www.genpathway.com (858) 457-3250
Comprehensive chromatin and methylated DNA immunoprecipitation (ChIP) assay and data analysis services for the discovery and identification of gene regulated events and pathways by studying transcription factor binding, gene transcription, and epigenetic events such as DNA methylation and histone modification.
Scientific Symposium April 27, 2010 mutagenesis, and shRNA plasmid construction. GENEWIZ Genomic Services: Fragment analysis, mutation analysis, and SNP discovery sequencing. Highly experienced with custom projects.
Julabo www.julabo.com (610) 231-0250
GENEWIZ www.genewiz.com (908) 222-0711
GENEWIZ is the trusted provider of award-winning DNA sequencing, gene synthesis, and other molecular biology and genomic services. GENEWIZ DNA Sequencing Services: High-throughput sequencing of DNA, bacteria, and phage supernatant. Primer walking and best-in-class sequencing of hairpin, RNAi, and GC-rich difficult templates. GENEWIZ Molecular Biology Services: Gene synthesis, plasmid preparations, site-directed
Since 1967, JULABO has been recognized as a market leader and technological innovator in producing temperature control instruments. JULABO produces temperature regulating equipment that circulates a thermal fluid for applications ranging from -91 to +335 °C. The product line varies from instruments that heat only (to +335 °C) to highly dynamic instruments with a wide temperature capability (-91 to +250 °C) to chillers with up to 20 kW cooling power. JULABO offers a variety of instruments specific to many applications. Our customers span from the pharmaceutical, petroleum, and semi-conductor industries to food preparation, academic laboratories and many others. Over the last 42 years JULABO has continually introduced new technology in their products allowing for higher levels of performance without complicated operation.
®
Li-Cor Biosciences www.licor.com 402-467-3576
LI-COR® Biosciences is a leading manufacturer of near-infrared imaging systems and IRDye infrared dye reagents for various applications, including quantitative Western Blotting, cell-based assays, small animal imaging, microscopy, and DNA fragment analysis. The company also offers accessories and reagents for other detection applications. LI-COR pioneered the development of near-infrared fluorescence detection systems for DNA sequencing and today provides systems for drug discovery, protein research, small animal imaging, and undergraduate training. LI-COR instruments for photosynthesis, carbon dioxide analysis and light measurement are recognized worldwide for standard-setting innovation in plant science research and environmental monitoring.
EXHIBITORS PromoCell www.promocell.com (866) 251-2860
Since PromoCell was established in 1990 in Heidelberg, our company has always endeavoured to support the trend towards carrying out in-vitro cell culture tests using normal human primary cells. As a result of the regular contact between the staff of our research and development department and other scientists, we have been able to provide, at an early stage, relevant high quality cell types together with serum-free or low-serum cell culture media. This programme has been steadily expanded and supplemented, with regard to cell biology, by the range of important growth factors and antibodies. PromoCell is now a global operation, with a distribution network spread across many countries.
SDIX /www.sdix.com (302) 456-6789
SDIX is a biotechnology company, expert at creating advantage by providing a broad range of quality, innovative and effective immuno-solutions to the Pharmaceutical, Biotechnology, Diagnostics, and Food Safety markets. For
Scientific Symposium April 27, 2010 20 years, SDIX has developed antibodies which advance its customers’ immuno-based work reducing time, labor, and costs while increasing accuracy and reliability of results. SDIX offers a full suite of integrated immuno-solution capabilities including assay design, development, and production. In life science markets, SDIX capabilities are being used to help discover the mechanisms of disease, facilitate the development of new drugs, and provide mechanisms for rapid diagnosis. SDIX has also developed a unique Genomic Antibody Technology™ platform which is fastest and most cost effective method for generating Abs against conformational epitopes.
TTP LABTECH www.ttplabtech.com (617) 494-9794
TTP LabTech supplies custom automation and laboratory instrumentation for the healthcare, biotech and pharmaceutical sectors. Its products include: comPOUND® modular cherry-picking sample store; mosquito® nanolitre liquid handler; and Acumen Explorer® imaging cytometer for ultra high throughput, high content screening assays.
ZenBio Stemcell Technologies www.stemcell.com (604) 877-0713
STEMCELL Technologies is committed to supporting stem cell and many other areas of life science research worldwide by providing enabling research tools that are innovative, timely and of consistently high quality. STEMCELL’s specialized media and cell separation products are available for a wide range of research applications, and are complemented by a diverse array of cytokines, antibodies, tissue culture reagents, as well as services including contract assays, proficiency testing, and training.
www.zen-bio.com (919) 547-0692
Zen-Bio, Inc. (ZB) is a leading global provider of advanced cell-based solutions and services to the life science, cosmetics, and personal care communities. The company, founded in 1995, was a pioneer in adipose derived stem cells (ASCs) and continues this legacy providing cutting edge human primary cell culture products and services. Our mission is to provide the highest quality human cell systems, reagents and contract services to our research partners, to develop and commercialize innovative research tools, leverage our expertise through research and development and strategic alliances, and accelerate discovery.
NON-PROFIT SPONSORS
AWIS http://awis-cjc.org
Our Mission: To empower and promote scientists in the local community through education, networking, service, leadership, entrepreneurship
BioPharma Research Council
Pennsylvania Biotechnology Center www.pabiotechbc.org
Pennsylvania Biotech Center The Pennsylvania Biotechnology Center of Bucks County is the result of a unique partnership to create an historic and transformational force from which discoveries will be born, students will be trained, and new companies will be launched.
BioPharma Research Council www.biopharmaresearchcouncil.org
The BioPharma Research Council (BRC) is an independent, nonprofit corporation focused on the needs of the biopharmaceutical research community and its product and service suppliers. Our objective is to provide educational resources to the scientific community. We believe that scientific discourse and debate is central to the research and development process. Yet many organizations have slashed their travel and professional development budgets. We hope to fill the void left by budget cuts, and provide a local forum for scientists to meet and share ideas on a broad variety of topics affecting the BioPharma Industry.
Regional Biotech Council www.ihvr.org/rbc/
The mission of the Regional Biotech Council is to provide a stimulating networking environment and strategic support for biotech entrepreneurs within the five county region of Southeastern Pennsylvania - Chester, Montgomery, Delaware, Philadelphia and Bucks. The Regional Biotech Council is hosted by the Institute of Hepatitis and Virus Research, the research affiliate of the Hepatitis B Foundation, and funded in part by a grant from Ben Franklin Technology Partners of Southeastern Pennsylvania.
Scientific Symposium April 27, 2010
SYMPOSIUM PRODUCED & MANAGED BY:
ABOUT US PlanetConnect, Inc. is in the business of producing internal proprietary life science events for Merck, Johnson & Johnson, BMS and other large Pharma. We also host external multi-Pharma/Biotech events and user groups throughout the U.S. For information about additionally scheduled Scientific Symposia and Tradeshows, visit events.planetconnect.com. If you are interested in speaking or exhibiting at our next events, send email to [email protected] or call 732-933-9473.
