Nanostructure Imaging Mass Spectrometry (NIMS)

Nanostructure Imaging Mass Spectrometry (NIMS)

Gary Siuzdak

Nanostructure Imaging Mass Spectrometry (NIMS) Molecular & Anatomical Imaging Gary Siuzdak

Nanostructure Imaging Mass Spectrometry (NIMS)

Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure Imaging Mass Spectrometry (NIMS)

Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure Imaging Mass Spectrometry

Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure Imaging Mass Spectrometry movie Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure Imaging Mass Spectrometry

No matrix deposition

Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure Imaging Mass Spectrometry

No matrix deposition No matrix background Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure Imaging Mass Spectrometry

No matrix deposition No matrix background Resolution corr w laser

Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure Imaging Mass Spectrometry

No matrix deposition No matrix background Resolution corr w laser NIMS is OCT friendly

Nature 1999 Nature 2007 Anal. Chem. 2004,‘07,08…12 Methods in Molecul. Biol. 2014

Nanostructure-Initiator Mass Spectrometry (NIMS) Brain C. elegans

Breast Cancer

Single Cancer Cells

Spleen

HT Screening

Nanostructure-Initiator Mass Spectrometry (NIMS)

Lung Cancer Metastasis suggested by Ralph J. DeBerardinis

Nanostructure Imaging Mass Spectrometry (NIMS) Imaging (NAMI) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Imaging (NAMI) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) Fluorinated Gold Nanoparticles (f-AuNP)

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP Electron Microscopy

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP Electron Microscopy

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP Electron Microscopy

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP Electron Microscopy

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP Electron Microscopy

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP Electron Microscopy

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP Electron Microscopy

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS)

MALDI

Nanostructure Imaging Mass Spectrometry (NIMS)

MALDI

Nanostructure Imaging Mass Spectrometry (NIMS)

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS)

Nanostructure Imaging Mass Spectrometry (NIMS)

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS) f-AuNP

Nanostructure Imaging Mass Spectrometry (NIMS)

X-ray

Molecular image

Nanostructure Imaging Mass Spectrometry (NIMS)

Anatomical & Molecular Molecular X-ray image Imaging

Nanostructure Imaging Mass Spectrometry (NIMS)

Anatomical & Molecular Molecular X-ray image Imaging

Nanostructure Imaging Mass Spectrometry (NIMS)

Anatomical & Molecular Molecular X-ray image Imaging

Nanostructure Imaging Mass Spectrometry (NIMS) Acknowledgements National Institutes of Health DoD and the DOE

Acknowledgements

Mike Kurczy

Jiang Zhu

Julijana Ivanisevic

Adam Schuyler

Acknowledgements - Pfizer

Mary Spilker

Kush Lalwani

Peter O’Brien

John David