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Role and trend of maternal antiretroviral therapy in preventing mother-to-child-transmission of HIV in sub-Saharan Africa 1 Olatunji Adetokunboh ,

2 Mojisola Oluwasanu

1Stellenbosch University, Division of Community Health, Cape Town, South Africa, 2University of Ibadan, Faculty of Public Health, Ibadan, Nigeria

Background

Results

Pediatric HIV infections are largely due to mother-to-child transmission (MTCT) in utero, during delivery, or via breastfeeding.

The final MTCT rate reduced from 27% to 19%, p=0.0001.

The percentage of HIV positive pregnant women receiving ART was 54% in 2012, MD 34%, p=0.0001.

Put a figure here that explores one particular outcome in a complicated table of results.

The highest burden of global pediatric HIV infections are in sub-Saharan Africa where many of the countries still have high MTCT rates and new pediatric HIV infections. This study seeks to determine the role and trend of antiretroviral therapy in HIV positive women with respect to reduction in MTCT rate in the high burden countries of SSA countries since 2009.

The percentage of women receiving ARVs to prevent MTCT was 63% in 2012, mean difference MD 30%, p=0.0001

Methods

Conclusions There has been a significant increase in ART coverage among HIV infected women in SSA in the last few years. Countries that have higher ART coverage tend to have lower MTCT rates thereby preventing many new infections. However there is still lot of work to be done to achieve total elimination.

Data were obtained from the Joint United Nations Programme on HIV/AIDS (UNAIDS) 2013 progress report on the Global Plan. The data were that of 21 sub- Saharan priority countries from 2009 to 2012. The priority countries in Africa are Angola, Botswana, Burundi, Cameroun, Chad, Cote d’Ivoire, Congo DR, Ethiopia, Ghana, Kenya, Lesotho, Malawi, Mozambique, Namibia, Nigeria, South Africa, Swaziland, Uganda, Tanzania, Zambia, Zimbabwe

The final MTCT rate was strongly negatively correlated with the percentage of women receiving ARVs to prevent MTCT (r=-0.9266; p< 0.0001).

Literature cited The percentage of women or infants receiving ARVs during breastfeeding was 43%, MD 33%, p=0.0001.

Our analysis focused on final MTCT rates, percentage and mean differences (MD) of women receiving antiretroviral agents (ARVs) to prevent MTCT, percentage of women or infants receiving ARVs during breastfeeding to prevent MTCT, percentage of HIV positive pregnant women receiving ART for their own health. Presented at HIVR4P 2014 – Cape Town, South Africa

1. Mofenson LM. Antiretroviral drugs to prevent breastfeeding HIV transmission. Antivir Ther 2010;15:537-553. 2. UNAIDS. Countdown to zero. Global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive. 2011–2015. Geneva, Switzerland: UNAIDS;2011. 3. UNAIDS. Progress report on global plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive. UNAIDS, Geneva, Switzerland: UNAIDS;2013.

Acknowledgments We acknowledge UNAIDS for the data used for this study. We thank HIV for Prevention 2014 organizers and partners for the award of the scholarship to attend the conference.

Email address: [email protected]

http://www.researchgate.net/profile/Olatunji_Adetokunboh/info