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Cancer Genome Anatomy Project Facilitate the interface of genomics and cancer research through the establishment of platform information and technology infrastructures ◆ Make all project resources accessible through public databases and resource centers ◆

Human Tumor Gene Index

Human Gene Discovery

Cancer Chromosome Aberration Project

Genetic Annotation Initiative

EST Sequencing

cDNA 3’ EST 5’ EST 5’ EST

UniGene Release 89

Growth of Human UniGene

Cluster Sizes for Human UniGene Build 84 25000

number of clusters

20000

15000

10000

5000

0 1

2

3,4

5,8

9,16 17-32 33-64 Cluster Size

65128

129- 257- 513256 512 1024

EST Representation in UniGene for Known Genes

Total UniGene Oncogenes/Tumor Suppressors Interleukins

Known Genes 8963 161 18

Genes with EST 7979 145 12

Percent 89 90 67

The Cancer Genome Anatomy Project (http://www.ncbi.nlm.nih.gov/ncicgap)

CGAP Resource Locator

Cancer Genome Anatomy Project Summary Table Selector - Colon Example

Cancer Genome Anatomy Project Summary Table - Colon Example

The Cancer Genome Anatomy Project Summary Table of Brain Libraries/Sequences

CGAP cDNA Library Browser

Digital Differential Display Prostate Example (1)

Digital Differential Display Prostate Example (2)

CGAP GeneExpress P53 Example

CGAP cDNA Expression Profiler

CGAP Tumor Suppressor and Oncogene Directory

CGAP Tumor Suppressor and Oncogene Directory VHL Example

CGAP Tumor Suppressor and Oncogene Directory VHL Example

CGAP Tumor Suppressor and Oncogene Directory VHL Example

CGAP Tumor Suppressor and Oncogene Directory VHL Example GGenbank

UniGene

OMIM IMAGE

Serial Analysis of Gene Expression

CGAP Serial Analysis of Gene Expression

CGAP Genetic Annotation Initiative

CGAP Genetic Annotation Initiative Home Page (http://lpg.nci.nih.gov/gai)

CGAP Genetic Annotation Initiative GST Example

CGAP Genetic Annotation Initiative GST Example

CGAP Genetic Annotation Initiative GST Example

CGAP Genetic Annotation Initiative GST Example

CGAP Genetic Annotation Initiative GST Example

CGAP Genetic Annotation Initiative Imagemaps Showing Genetic Locations of Confirmed and Predicted SNPs

CGAP Genetic Annotation Initiative Map Locations of Identified SNPs