Supporting Information - AWS
Supporting Information Chemoradiotherapeutic Magnetic Nanoparticles for Targeted Treatment of Non-Small Cell Lung Cancer Imalka Munaweera1‡, Yi Shi2‡, Bhuvaneswari Koneru2, Ruben Saez3, Ali Aliev1, Anthony J. Di Pasqua2*, Kenneth J. Balkus Jr.1*
1
Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, United States
2
Depatment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States
3
Texas Health Research and Education Institute, Plano, TX 75093, United States
E-mail: [email protected], [email protected]
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Figure S1. PXRD pattern of (a) HoIG powder (b) Fe5Ho3O12; JCPDS 00-023-0282
Figure S2. Digital image of HoIG powder attracted to a magnet
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Figure S3. Crystal structure (cubic, Ia3d) of garnet calculated using the crystallographic data in reference 1 Holmium iron garnet (HoIG) is a member of the isostructural garnet family and ferrimagnetic oxides. The general formula for a garnet is C3A2D3O12 where the C cations occupy dodecahedral sites, the A cations occupy octahedral sites, and the D cations occupy tetrahedral sites in the crystal structure as shown in Figure S3. In the case of HoIG; (Ho3)C{Fe2}D[Fe3]AO12, 24Ho3+ occupies dodecahedral sites and 16Fe3+ occupies octahedral sites and 24Fe3+ occupies tetrahedral sites.2
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Figure S4. FTIR spectra of (a-1, b-1, c-1) HoIG, (a-2) HoIG-cisplatin, (b-2) HoIGcarboplatin, (c-2) HoIG-oxaliplatin, (a-3) cisplatin, (b-3) carboplatin, (c-3) oxaliplatin
Figure S5. The platinum drugs and possible ligand interaction with the HoIG
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Figure S6. EDX mapping and spectrum of cisplatin loaded HoIG
Figure S7. EDX mapping and spectrum of carboplatin loaded HoIG
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Figure S8. EDX mapping and spectrum of oxaliplatin loaded HoIG
Figure S9. First order model for drug release from (a) HoIG-cisplatin (b) HoIG-carboplatin (c) HoIG -oxaliplatin
References [1] T. Komori, T. Sakakura, Y. Takenaka, K.Tanaka, T.Okuda, Acta Crystallogr. Sect. E. 2009, 65, 72. [2] M. S. Lataifeh, J. Phys. Soc. Jpn. 2000, 69, 2280.
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1
Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, United States
2
Depatment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, United States
3
Texas Health Research and Education Institute, Plano, TX 75093, United States
E-mail: [email protected], [email protected]
Page S1
Figure S1. PXRD pattern of (a) HoIG powder (b) Fe5Ho3O12; JCPDS 00-023-0282
Figure S2. Digital image of HoIG powder attracted to a magnet
Page S2
Figure S3. Crystal structure (cubic, Ia3d) of garnet calculated using the crystallographic data in reference 1 Holmium iron garnet (HoIG) is a member of the isostructural garnet family and ferrimagnetic oxides. The general formula for a garnet is C3A2D3O12 where the C cations occupy dodecahedral sites, the A cations occupy octahedral sites, and the D cations occupy tetrahedral sites in the crystal structure as shown in Figure S3. In the case of HoIG; (Ho3)C{Fe2}D[Fe3]AO12, 24Ho3+ occupies dodecahedral sites and 16Fe3+ occupies octahedral sites and 24Fe3+ occupies tetrahedral sites.2
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Figure S4. FTIR spectra of (a-1, b-1, c-1) HoIG, (a-2) HoIG-cisplatin, (b-2) HoIGcarboplatin, (c-2) HoIG-oxaliplatin, (a-3) cisplatin, (b-3) carboplatin, (c-3) oxaliplatin
Figure S5. The platinum drugs and possible ligand interaction with the HoIG
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Figure S6. EDX mapping and spectrum of cisplatin loaded HoIG
Figure S7. EDX mapping and spectrum of carboplatin loaded HoIG
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Figure S8. EDX mapping and spectrum of oxaliplatin loaded HoIG
Figure S9. First order model for drug release from (a) HoIG-cisplatin (b) HoIG-carboplatin (c) HoIG -oxaliplatin
References [1] T. Komori, T. Sakakura, Y. Takenaka, K.Tanaka, T.Okuda, Acta Crystallogr. Sect. E. 2009, 65, 72. [2] M. S. Lataifeh, J. Phys. Soc. Jpn. 2000, 69, 2280.
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