Supramolecular Catalysis within Peptidic Molecular Gel
23rd IUPAC Conference on Physical Organic Chemistry (ICPOC23) 3rd – 8th July 2016 • Sydney • Australia
Supramolecular Catalysis within Peptidic Molecular Gel Networks N. Singh,a M. Araújo and B. Escuder,a,* a
Dep. Química Inorgànica i Orgànica, Universitat Jaume I, E-12071 Castelló, Spain *[email protected]
Molecular gels are attractive soft materials formed by the self-assembly of low molecular weight compounds by non-covalent interactions. They constitute an example of the autonomous bottom-up construction of a material from small molecular components programed at the molecular level with functional information. In this sense, synthetically simple molecules can be prepared bearing active functional groups that will provide a functional material after self-assembly. The newly formed materials not only could retain the properties of their single components but could develop new features arising from the cooperation of arrays of functional groups.1 Additionally, molecular gels can be stimuli responsive and the sol-to-gel transition can be switched on and off at will with physical or chemical stimuli such as light, ultrasounds, temperature, pH and reactive compounds among others. 2 Taking nature as inspiration, short peptides and pseudopeptides have been used to construct simple as well as multicomponent ‘enzyme-like’ catalytic networks that are active for reactions of different complexity (single substrate, tandem, autocatalytic, organocatalysis, metallocatalysis, etc…). Several examples reported by the group will be presented.3
References 1. Escuder, B.; Miravet, J. F. (Eds.), Functional Molecular Gels, RSC Soft Matter Series, Cambridge, 2014. 2. Segarra-Maset, M. D.; Nebot, V. J.; Miravet, J. F.; Escuder B. Chem. Soc. Rev. 2013, 42, 7086-7098. 3. a) Singh, N.; Conte, M. P.; Ulijn, R. V.; Miravet, J. F.; Escuder, B. Chem. Commun. 2015, 51, 13213-13216. b) Tena-Solsona, M.; Nanda, J.; Díaz-Oltra, S.; Chotera, A.; Ashkenasy, G.; Escuder, B. Chem. Eur. J. 2016, in press. c) Araújo, M.; Díaz-Oltra, S.; Escuder, B. Chem. Eur. J. 2016, in press.
ILC17
Supramolecular Catalysis within Peptidic Molecular Gel Networks N. Singh,a M. Araújo and B. Escuder,a,* a
Dep. Química Inorgànica i Orgànica, Universitat Jaume I, E-12071 Castelló, Spain *[email protected]
Molecular gels are attractive soft materials formed by the self-assembly of low molecular weight compounds by non-covalent interactions. They constitute an example of the autonomous bottom-up construction of a material from small molecular components programed at the molecular level with functional information. In this sense, synthetically simple molecules can be prepared bearing active functional groups that will provide a functional material after self-assembly. The newly formed materials not only could retain the properties of their single components but could develop new features arising from the cooperation of arrays of functional groups.1 Additionally, molecular gels can be stimuli responsive and the sol-to-gel transition can be switched on and off at will with physical or chemical stimuli such as light, ultrasounds, temperature, pH and reactive compounds among others. 2 Taking nature as inspiration, short peptides and pseudopeptides have been used to construct simple as well as multicomponent ‘enzyme-like’ catalytic networks that are active for reactions of different complexity (single substrate, tandem, autocatalytic, organocatalysis, metallocatalysis, etc…). Several examples reported by the group will be presented.3
References 1. Escuder, B.; Miravet, J. F. (Eds.), Functional Molecular Gels, RSC Soft Matter Series, Cambridge, 2014. 2. Segarra-Maset, M. D.; Nebot, V. J.; Miravet, J. F.; Escuder B. Chem. Soc. Rev. 2013, 42, 7086-7098. 3. a) Singh, N.; Conte, M. P.; Ulijn, R. V.; Miravet, J. F.; Escuder, B. Chem. Commun. 2015, 51, 13213-13216. b) Tena-Solsona, M.; Nanda, J.; Díaz-Oltra, S.; Chotera, A.; Ashkenasy, G.; Escuder, B. Chem. Eur. J. 2016, in press. c) Araújo, M.; Díaz-Oltra, S.; Escuder, B. Chem. Eur. J. 2016, in press.
ILC17
