World-class manufacturing capabilities for Licaps® Fusion Technology

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Manufacturing

World-class manufacturing capabilities for Licaps® Fusion Technology World-class manufacturing capability • 4 locations for a global reach

Greenwood Manufacturing

Ploërmel Manufacturing

Colmar Manufacturing

Sagamihara Manufacturing

• FDA inspected • Pilot and Commercial scale manufacturing • Licaps® production capability

• FDA & EMA inspected • Pilot and Commercial scale manufacturing • Licaps® and Softgel production capability

• FDA accredited (food) • Pilot and Commercial scale manufacturing • Licaps® production capability

• Dietary supplement products • Pilot and Commercial scale manufacturing • Licaps® production capability

Best-in-Class pharmaceutical manufacturing plants • State-of-the-art manufacturing facilities approved by the FDA and EMA • Robust product flow management from raw material to marketed product

 omprehensive formulation development and manufacturing C capabilities speeds your product to market • From simple to complex formulas • EHS certification up to OEB 5

Well supported technology transfer and simple scale-up • Flexibility of manufacturing at Capsugel

www.capsugel.com

Manufacturing

Licaps® Fusion Technology: A new era in liquid-filled capsule manufacturing Latest generation of Capsugel’s proprietary Fusion Sealing technology • High performance equipment with minimal waste of API and excipients • Capsule requires less sealant and delivers an enhanced seal • Robust and cost-effective delivery of bioavailability-enhancing formulations

A robust and precise manufacturing process Delivering quality products with minimal use of resources New high-precision filling pump Delivers excellent clean filling

New capsule transfer system Secure capsule transfer for low viscosity or hot melt formulas

Capsule filling machine

Capsule sealing machine with Fusion Technology

Licaps® Fusion Technology enables the delivery of fast-acting liquid formulations, protected from atmospheric moisture and oxygen in a unique fused hard capsule dosage form

www.capsugel.com

©2012 Capsugel Belgium NV. All rights reserved. 2012 09004

New in-line inspection system Checks seal zone and weight of every capsule