WSS

Flow from the Bicuspid Aortic Valve Promotes Acute Remodeling Ex Vivo in the Convex Region but not the Concave Region of Porcine Ascending Aortas Samantha K. Atkins, Philippe Sucosky

University of Notre Dame, Department of Aerospace and Mechanical Engineering, Notre Dame IN

noncoronary leaflet

dilation site

helical flow

tissue samples isolation

healthy porcine aorta

TAV AA

BAV AA (Mahadevia et al. Circ 2014)

tissue samples sutured on plate

◊ Samples from AA convexity exposed to TAV AA or BAV AA convexity WSS ◊ Samples from AA concavity exposed to TAV AA or BAV AA concavity WSS ◊ 48-hour culture duration

600

*#%

*#

400

*#%

200 0 Fresh

*P < 0.05 vs. fresh

#P