Additional file Figure S4 - BioMed Central
0.00 0.14
KSS 3' breaks (69)
0.04
0.02
KSS: 73 deletions 0.10
PEO 5' breaks
(59)
PEO 3' breaks
(57)
0.08
0.06
0.04
PEO: 60 deletions
0.12
0.10
0.02 0.02
0.00 0.00 Up To 0 400 To 500 900 To 1000 1400 To 1500 1900 To 2000 2400 To 2500 2900 To 3000 3400 To 3500 3900 To 4000 4400 To 4500 4900 To 5000 5400 To 5500 5900 To 6000 6400 To 6500 6900 To 7000 7400 To 7500 7900 To 8000 8400 To 8500 8900 To 9000 9400 To 9500 9900 To 10000 10400 To 10500 10900 To 11000 11400 To 11500 11900 To 12000 12400 To 12500 12900 To 13000 13400 To 13500 13900 To 14000 14400 To 14500 14900 To 15000 15400 To 15500 15900 To 16000 16400 To 16500
0.06 0.12
Fraction of total Count
KSS 5' breaks (72)
Up To 0 400 To 500 900 To 1000 1400 To 1500 1900 To 2000 2400 To 2500 2900 To 3000 3400 To 3500 3900 To 4000 4400 To 4500 4900 To 5000 5400 To 5500 5900 To 6000 6400 To 6500 6900 To 7000 7400 To 7500 7900 To 8000 8400 To 8500 8900 To 9000 9400 To 9500 9900 To 10000 10400 To 10500 10900 To 11000 11400 To 11500 11900 To 12000 12400 To 12500 12900 To 13000 13400 To 13500 13900 To 14000 14400 To 14500 14900 To 15000 15400 To 15500 15900 To 16000 16400 To 16500
0.08
Fraction of total Count
0.10
Up To 0 400 To 500 900 To 1000 1400 To 1500 1900 To 2000 2400 To 2500 2900 To 3000 3400 To 3500 3900 To 4000 4400 To 4500 4900 To 5000 5400 To 5500 5900 To 6000 6400 To 6500 6900 To 7000 7400 To 7500 7900 To 8000 8400 To 8500 8900 To 9000 9400 To 9500 9900 To 10000 10400 To 10500 10900 To 11000 11400 To 11500 11900 To 12000 12400 To 12500 12900 To 13000 13400 To 13500 13900 To 14000 14400 To 14500 14900 To 15000 15400 To 15500 15900 To 16000 16400 To 16500
Fraction of total Count 0.12 0.14 PS 5' breaks (26)
PS 3' breaks (26)
0.08
0.06
0.04
PS: 27 deletions
Additional file Figure S4. Histogram of 5’ and 3‘ breakpoints in mtDNA deletions occuring in PSS, PEO, and PS.
KSS 3' breaks (69)
0.04
0.02
KSS: 73 deletions 0.10
PEO 5' breaks
(59)
PEO 3' breaks
(57)
0.08
0.06
0.04
PEO: 60 deletions
0.12
0.10
0.02 0.02
0.00 0.00 Up To 0 400 To 500 900 To 1000 1400 To 1500 1900 To 2000 2400 To 2500 2900 To 3000 3400 To 3500 3900 To 4000 4400 To 4500 4900 To 5000 5400 To 5500 5900 To 6000 6400 To 6500 6900 To 7000 7400 To 7500 7900 To 8000 8400 To 8500 8900 To 9000 9400 To 9500 9900 To 10000 10400 To 10500 10900 To 11000 11400 To 11500 11900 To 12000 12400 To 12500 12900 To 13000 13400 To 13500 13900 To 14000 14400 To 14500 14900 To 15000 15400 To 15500 15900 To 16000 16400 To 16500
0.06 0.12
Fraction of total Count
KSS 5' breaks (72)
Up To 0 400 To 500 900 To 1000 1400 To 1500 1900 To 2000 2400 To 2500 2900 To 3000 3400 To 3500 3900 To 4000 4400 To 4500 4900 To 5000 5400 To 5500 5900 To 6000 6400 To 6500 6900 To 7000 7400 To 7500 7900 To 8000 8400 To 8500 8900 To 9000 9400 To 9500 9900 To 10000 10400 To 10500 10900 To 11000 11400 To 11500 11900 To 12000 12400 To 12500 12900 To 13000 13400 To 13500 13900 To 14000 14400 To 14500 14900 To 15000 15400 To 15500 15900 To 16000 16400 To 16500
0.08
Fraction of total Count
0.10
Up To 0 400 To 500 900 To 1000 1400 To 1500 1900 To 2000 2400 To 2500 2900 To 3000 3400 To 3500 3900 To 4000 4400 To 4500 4900 To 5000 5400 To 5500 5900 To 6000 6400 To 6500 6900 To 7000 7400 To 7500 7900 To 8000 8400 To 8500 8900 To 9000 9400 To 9500 9900 To 10000 10400 To 10500 10900 To 11000 11400 To 11500 11900 To 12000 12400 To 12500 12900 To 13000 13400 To 13500 13900 To 14000 14400 To 14500 14900 To 15000 15400 To 15500 15900 To 16000 16400 To 16500
Fraction of total Count 0.12 0.14 PS 5' breaks (26)
PS 3' breaks (26)
0.08
0.06
0.04
PS: 27 deletions
Additional file Figure S4. Histogram of 5’ and 3‘ breakpoints in mtDNA deletions occuring in PSS, PEO, and PS.
