Development and Characterization of Amorphous Nanofiber Drug ...
Supporting information
Development and Characterization of Amorphous Nanofiber Drug Dispersions Prepared Using Pressurized Gyration Bahijja Tolulope Raimi-Abraham1, Suntharavathanan Mahalingam2, Philip J Davies3, Mohan Edirisinghe2, Duncan Q.M Craig1*
1
University College London School of Pharmacy, 29-39 Brunswick Square, London, WC1N
1AX, U.K. 2
Department of Mechanical Engineering, University College London, Torrington Place,
London, WC1E 7JE, U.K. 3
TA Instruments – A Division of Waters U.K., 730-740 Centennial Court, Centennial Park,
Elstree, WD6 3SZ, U.K. *Correspondence: [email protected]
Keywords (max 6 words) Solid dispersion, amorphous, pressurized gyration, PVP, supersaturation, ibuprofen
1
Supporting information Characterization of solution parameters Solution viscosity and surface tension
b) Figure SI1. a) Viscosity (mPa s) and b) Surface Tension (mN m-1) at 25 °C of K90F (represented as 0 %w/v ibuprofen ), K90F, 10, 30 and 50% IBU-K90F solutions in ethanol.
2
Supporting information Thermal characterization of fibers Table SI1 Weight loss (%) of IBU, K90F, IBU-K90F PMs and PG fibers as measured by thermogravimetric analysis WEIGHT LOSS
Sample (%)
IBU
0.1%
K90F
3.0%
IBU-K90F 10 % PM
3.2%
IBU-K90F 30 % PM
2.3%
IBU-K90F 50 % PM
2.4%
K90F PG Fibers
6.5%
IBU-K90F 10 % PG Fibers
5.5%
IBU-K90F 30 % PG Fibers
4.1%
IBU-K90F 50 % PG Fibers
3.0%
3
Supporting information
Sample: K90F_I_10 PG Fibres_1 Size: 2.9200 mg Method: Quasi
File: C:...\K90F +I\K90F_I_10 PG Fibres_1.002a Operator: Bahijja Run Date: 20-Jun-2014 16:17 Instrument: DSC Q2000 V24.11 Build 124
DSC
Rev Heat Flow (W/g)
-0.0240
-0.0282
120
a)
b) Sample: K90F_I_30 PG Fibres_2 Size: 1.2000 mg Method: Quasi
DSC
130
File: C:...\K90F +I\K90F_I_30 PG Fibres_2.001 Operator: Bahijja Run Date: 21-Jun-2014 12:41 Instrument: DSC Q2000 V24.11 Build 124
140
150
160
Temperature (°C)
Exo Up
Sample: K90F_I_50 PG Fibres_2 Size: 2.4500 mg Method: Quasi
DSC
170 Universal V4.5A TA Instruments
File: C:...\K90F +I\K90F_I_50 PG Fibres_2.001 Operator: Bahijja Run Date: 22-Jun-2014 02:18 Instrument: DSC Q2000 V24.11 Build 124
-0.046
-0.0175
Rev Heat Flow (W/g)
Rev Heat Flow (W/g)
-0.047
-0.0275
-0.048
-0.049
-0.0375
90
c)
110
Exo Up
130
Temperature (°C)
150
170 Universal V4.5A TA Instruments
100
d)
Exo Up
110
120
Temperature (°C)
130
140 Universal V4.5A TA Instruments
Figure SI2 Reversing signal of MTDSC data for a) K90F PG fibers IBU-K90F b) 10% c) 30% and d) 50% PG fibers
Solubility studies
Figure SI3. Solubility IBU in 0.1M HCl (represented as 0 % K90F %w/v solution) and in K90F 0.5, 1, 1.5 and 2% w/v 4
Development and Characterization of Amorphous Nanofiber Drug Dispersions Prepared Using Pressurized Gyration Bahijja Tolulope Raimi-Abraham1, Suntharavathanan Mahalingam2, Philip J Davies3, Mohan Edirisinghe2, Duncan Q.M Craig1*
1
University College London School of Pharmacy, 29-39 Brunswick Square, London, WC1N
1AX, U.K. 2
Department of Mechanical Engineering, University College London, Torrington Place,
London, WC1E 7JE, U.K. 3
TA Instruments – A Division of Waters U.K., 730-740 Centennial Court, Centennial Park,
Elstree, WD6 3SZ, U.K. *Correspondence: [email protected]
Keywords (max 6 words) Solid dispersion, amorphous, pressurized gyration, PVP, supersaturation, ibuprofen
1
Supporting information Characterization of solution parameters Solution viscosity and surface tension
b) Figure SI1. a) Viscosity (mPa s) and b) Surface Tension (mN m-1) at 25 °C of K90F (represented as 0 %w/v ibuprofen ), K90F, 10, 30 and 50% IBU-K90F solutions in ethanol.
2
Supporting information Thermal characterization of fibers Table SI1 Weight loss (%) of IBU, K90F, IBU-K90F PMs and PG fibers as measured by thermogravimetric analysis WEIGHT LOSS
Sample (%)
IBU
0.1%
K90F
3.0%
IBU-K90F 10 % PM
3.2%
IBU-K90F 30 % PM
2.3%
IBU-K90F 50 % PM
2.4%
K90F PG Fibers
6.5%
IBU-K90F 10 % PG Fibers
5.5%
IBU-K90F 30 % PG Fibers
4.1%
IBU-K90F 50 % PG Fibers
3.0%
3
Supporting information
Sample: K90F_I_10 PG Fibres_1 Size: 2.9200 mg Method: Quasi
File: C:...\K90F +I\K90F_I_10 PG Fibres_1.002a Operator: Bahijja Run Date: 20-Jun-2014 16:17 Instrument: DSC Q2000 V24.11 Build 124
DSC
Rev Heat Flow (W/g)
-0.0240
-0.0282
120
a)
b) Sample: K90F_I_30 PG Fibres_2 Size: 1.2000 mg Method: Quasi
DSC
130
File: C:...\K90F +I\K90F_I_30 PG Fibres_2.001 Operator: Bahijja Run Date: 21-Jun-2014 12:41 Instrument: DSC Q2000 V24.11 Build 124
140
150
160
Temperature (°C)
Exo Up
Sample: K90F_I_50 PG Fibres_2 Size: 2.4500 mg Method: Quasi
DSC
170 Universal V4.5A TA Instruments
File: C:...\K90F +I\K90F_I_50 PG Fibres_2.001 Operator: Bahijja Run Date: 22-Jun-2014 02:18 Instrument: DSC Q2000 V24.11 Build 124
-0.046
-0.0175
Rev Heat Flow (W/g)
Rev Heat Flow (W/g)
-0.047
-0.0275
-0.048
-0.049
-0.0375
90
c)
110
Exo Up
130
Temperature (°C)
150
170 Universal V4.5A TA Instruments
100
d)
Exo Up
110
120
Temperature (°C)
130
140 Universal V4.5A TA Instruments
Figure SI2 Reversing signal of MTDSC data for a) K90F PG fibers IBU-K90F b) 10% c) 30% and d) 50% PG fibers
Solubility studies
Figure SI3. Solubility IBU in 0.1M HCl (represented as 0 % K90F %w/v solution) and in K90F 0.5, 1, 1.5 and 2% w/v 4
