Direct Amidation of carboxylic acids using a Borate Ester Questions 1 ...

Download PDF
Comment
Report 1 Downloads 14 Views
Direct Amidation of carboxylic acids using a Borate Ester Questions

1. Calculate the Atom Economy of the reaction π΄π‘‘π‘œπ‘š πΈπ‘π‘œπ‘›π‘œπ‘šπ‘¦ (𝐴𝐸 ) =

π‘€π‘Š π‘œπ‘“ π‘π‘Ÿπ‘œπ‘‘π‘’π‘π‘‘(𝑠) Γ— 100% π‘€π‘Š π‘œπ‘“ π‘Žπ‘™π‘™ π‘Ÿπ‘’π‘Žπ‘π‘‘π‘Žπ‘›π‘‘π‘ 

2. Calculate the Reaction Mass Efficiency (RME) of the reaction 𝑅𝑀𝐸 =

π‘šπ‘Žπ‘ π‘  π‘œπ‘“ π‘–π‘ π‘œπ‘™π‘Žπ‘‘π‘’π‘‘ π‘π‘Ÿπ‘œπ‘‘π‘’π‘π‘‘ Γ— 100% π‘‘π‘œπ‘‘π‘Žπ‘™ π‘šπ‘Žπ‘ π‘  π‘œπ‘“ π‘Ÿπ‘’π‘Žπ‘π‘‘π‘Žπ‘›π‘‘π‘ 

3. Calculate the Mass Intensity (MI) of the reaction π‘€π‘Žπ‘ π‘  𝐼𝑛𝑑𝑒𝑛𝑠𝑖𝑑𝑦 (𝑀𝐼) =

π‘‘π‘œπ‘‘π‘Žπ‘™ π‘šπ‘Žπ‘ π‘  𝑖𝑛 π‘Ž π‘π‘Ÿπ‘œπ‘π‘’π‘ π‘  π‘œπ‘Ÿ π‘π‘Ÿπ‘œπ‘π‘’π‘ π‘  𝑠𝑑𝑒𝑝 π‘šπ‘Žπ‘ π‘  π‘œπ‘“ π‘π‘Ÿπ‘œπ‘‘π‘’π‘π‘‘

4. What proportion of the Mass Intensity is attributable to the work-up procedure?

5. What conclusions can you draw about the efficiency of the reaction from these calculations?

This education and training material has been created with funding from the Innovative Medicines Initiative Joint Undertaking under grant agreement nΒ°115360, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution The views expressed in regards to education and training materials represent the aspiration of the CHEM21 consortium, although may not always be the view of each individual organisation

Recommend Documents