IBM Watson into the Valley of Death
Pathology Informatics Summit 2014 Pittsburgh, PA
IBM Watson into the Valley of Death
Mark S. Boguski, M.D., Ph.D. May 14, 2014
According to
&
“IBM’s Watson could outperform doctors because it can read all existing medical journals and textbooks in less time than the doctor’s coffee break.”
Biology’s first “big data” problem GenBank
Cumulative growth of peer-reviewed publications vs. DNA sequences 1974-2000
Knowledge Gap
PubMed
Boguski, MS. Biosequence Exegesis. Science 1999 Oct 15;286(5439):453-5
Nature Reviews Drug Discovery 2011 Aug 31;10(9):712
Also Nature 2012 March 29;483:531
Fixing Irreproducibility Proposed NIH Actions • Training for postdocs in experimental design & responsible conduct of research • Grant review process changes: checklist & evaluation of scientific premise • Greater data transparency & citation
Nature 2014 January 30;505:612
Fixing Irreproducibility Proposed NIH Actions • Training for postdocs in experimental design & responsible conduct of research • Grant review process changes: checklist & evaluation of scientific premise • Greater data transparency & citation
Community Responsibility • Academic institutions should award promotion and tenure based on confirmatory or negative findings published in second tier journals
Nature 2014 January 30;505:612
How do we get outta here?
New Paradigm for the Laboratory Diagnosis of Cancer
Boguski MS, Arnaout R, Hill C. Customized care 2020: how medical sequencing and network biology will enable personalized medicine. F1000 Biol Rep. 1:7 doi:10.3410/B1-73, 2009
Watson’s Current Limitations
Biomedical Informatics: The Beginning
Dr. Robert Ledley (1926-2012) "Reasoning Foundations of Medical Diagnosis" Science 130: 9–21; 1959. "Digital Electronic Computers in Biomedical Science" Science 130: 1225–1234; 1959.
Suggested Reading and Viewing • Biosequence Exegesis – http://www.markboguski.net/docs/publications/Boguski-exegesis.pdf
• Customized Care 2020: Medical Genomics, Network Biology & Personalized Medicine – http://f1000.com/prime/reports/b/1/73
• Pathologists and the third wave of medical genomics – http://www.futuremedicine.com/doi/pdfplus/10.2217/pme.12.27
• The Idolatry of the $1,000 Genome – http://vimeo.com/58578986
• IBM Watson: Fighting the Last War – http://www.forbes.com/sites/jimgolden/2013/04/23/watson-fighting-the-lastwar/
www.markboguski.net
The Charge of the Light Brigade
IBM Watson into the Valley of Death
Mark S. Boguski, M.D., Ph.D. May 14, 2014
According to
&
“IBM’s Watson could outperform doctors because it can read all existing medical journals and textbooks in less time than the doctor’s coffee break.”
Biology’s first “big data” problem GenBank
Cumulative growth of peer-reviewed publications vs. DNA sequences 1974-2000
Knowledge Gap
PubMed
Boguski, MS. Biosequence Exegesis. Science 1999 Oct 15;286(5439):453-5
Nature Reviews Drug Discovery 2011 Aug 31;10(9):712
Also Nature 2012 March 29;483:531
Fixing Irreproducibility Proposed NIH Actions • Training for postdocs in experimental design & responsible conduct of research • Grant review process changes: checklist & evaluation of scientific premise • Greater data transparency & citation
Nature 2014 January 30;505:612
Fixing Irreproducibility Proposed NIH Actions • Training for postdocs in experimental design & responsible conduct of research • Grant review process changes: checklist & evaluation of scientific premise • Greater data transparency & citation
Community Responsibility • Academic institutions should award promotion and tenure based on confirmatory or negative findings published in second tier journals
Nature 2014 January 30;505:612
How do we get outta here?
New Paradigm for the Laboratory Diagnosis of Cancer
Boguski MS, Arnaout R, Hill C. Customized care 2020: how medical sequencing and network biology will enable personalized medicine. F1000 Biol Rep. 1:7 doi:10.3410/B1-73, 2009
Watson’s Current Limitations
Biomedical Informatics: The Beginning
Dr. Robert Ledley (1926-2012) "Reasoning Foundations of Medical Diagnosis" Science 130: 9–21; 1959. "Digital Electronic Computers in Biomedical Science" Science 130: 1225–1234; 1959.
Suggested Reading and Viewing • Biosequence Exegesis – http://www.markboguski.net/docs/publications/Boguski-exegesis.pdf
• Customized Care 2020: Medical Genomics, Network Biology & Personalized Medicine – http://f1000.com/prime/reports/b/1/73
• Pathologists and the third wave of medical genomics – http://www.futuremedicine.com/doi/pdfplus/10.2217/pme.12.27
• The Idolatry of the $1,000 Genome – http://vimeo.com/58578986
• IBM Watson: Fighting the Last War – http://www.forbes.com/sites/jimgolden/2013/04/23/watson-fighting-the-lastwar/
www.markboguski.net
The Charge of the Light Brigade
