Live Yeast and Yeast Cell Wall
Live Yeast and Yeast Cell Wall
FAQs Live Yeast
How is live yeast defined as a feed additive?
Live yeast is active dry yeast (ADY) that must contain no less than 15 billion live cells/gram (15B CFU/gram) of live yeast count.
How does live yeast work in animals?
Specific strains of live S. cerevisiae have demonstrated their ability to scavenge ruminal oxygen. Live yeast consumes oxygen entering the rumen with feed and mastication, lowering redox potential and enhances the conversion of lactic acid to propionic acid. Live yeast also helps metabolize glucose (making it less available for fermentative bacteria), stimulates metabolism of lactate, stabilizes rumen pH and helps prevent acidosis. In addition, research indicates it increases the total number of beneficial bacteria in the rumen.
Can live yeast be pelleted?
Since pelleting conditions favor higher temperature, protected or coated yeast such as BioSaf® Sc 47 HR+, are specially designed to tolerate temperatures as high as 198°F (92C). This is a 32% increase in heat resistance over Procreatin-7® (P7), a standard (unprotected) live yeast, making it ideal for pelleted feed. P7 is thermostable up to 150° F (65.5C) with optimum levels of surviving live yeast and is an excellent choice for non-pelleted feed.
How stable is live yeast and Yeast Cell Wall (YCW) in a commodity shed with moisture and other environmental elements?
Live yeast is susceptible to moisture and environmental conditions. Stability is dependent on yeast strain, how the live yeast is manufactured, if it is protected and how it’s packaged. Yeast cell wall is stable under a variety of environmental conditions.
Would there be a benefit in feeding both live yeast and YCW?
Yes, increased benefits have been seen when a combination is used. The benefits seen are dependent on species, production stage, and its intended use. Live yeast helps promote: • Optimum rumen fermentation • Stabilization of rumen pH (lower risk of acidosis) • An increase in Dry Matter Intake • Fiber digestion to increase Milk Fat YCW may be fed to help: • Stimulate immune function • Protect against pathogens • Improve growth of young animals Live yeast and YCW are different but complementary for the overall benefit of animal health and performance.
What groups of animals on my farm would benefit from live yeast and YCW products?
All animals would be expected to benefit from using a yeast based product. The returns would be dependent on intended use, ration make up and environmental conditions.
What research do you have vs. competitive products?
Phibro live yeast and YCW products have been tested against competitive products and have shown advantages over other yeast products. Phibro has a system in place to maintain the primary strain of yeast to ensure each harvested batch is a pure, single-strain. Our highly controlled manufacturing process ensures the consistency of products from lot to lot.
FAQs Live Yeast Will live yeast be alive when it gets to the animal?
Live yeasts are viable, meaning they are metabolically active in the animal. For ruminants, live yeast are active in the rumen, however, a portion escapes the rumen and is active in the gastrointestinal tract similar to non-ruminant animals. However, the rate/amount in the lower gastrointestinal tract will be dependent on the ration provided to the animal.
Do live yeast and YCW work with ionophores?
Yes, live yeast and yeast cell walls both work in synergy with ionophores and are commonly used in practice together.
What is the Feeding Rate for live yeast?
BioSaf Sc47 HR+ Feeding Rate
BioSaf Sc47 HR+
Ration
GRAMS/HD/DAY
Adult Cow
5
Calf/Heifer
5
Procreatin-7 (P7) Feeding Rate
Procreatin-7 (P7)
Ration
GRAMS/HD/DAY
Adult Cow
4
Calf/Heifer
4
Does P7 survive mineral mixes and acids?
Tests done to check stability of P7 in mineral premix showed that levels remained consistent over the 8 week test period. Also, P7 tested in commercial dairy feed, in the presence of organic acids, remained stable for 6 weeks.
Will live yeast help with milk components?
Feeding live yeast, such as P7 or BioSaf Sc47 HR+, will assist with improving milk components, caused by rumen dysfunction. An example of this is when wild yeast has suppressed Milk Fat.
Yeast is yeast, isn’t it?
Not all yeasts are the same. The most common type of yeast used in animal agriculture is Saccharomyces cerevisiae. Strains of S. cerevisiae are selected for various applications: alcohol production, wine flavor production, ethanol production, high sugar bread applications, yeast extract yield and animal bacterial challenges, just to name a few. Different strains of yeast have different glucan/mannan content and helical structures, which can change their biological activity. Yeast manufacturing methods can also alter its biological activity.
Is there published research on yeast products?
We have several published articles in a wide variety of scientific journals. These are available on request.
Why would I need to add yeast to my rations if I am balancing my diets with adequate amounts of fiber? Yeast may be beneficial in digesting fiber, making it more available to the animal. Specific live yeasts have the ability to scavenge oxygen and help prevent the accumulation of lactate, which helps stabilize the rumen pH and reduce rumen acidosis. Live yeast may help modify the rumen microflora, which increases the fibrolytic bacteria (Fibrobacter and Ruminococcus) and lactate utilizing bacteria (Megasphera and Selenomonas), preventing the accumulation of lactate and allowing for better fiber digestion.
FAQs Yeast Cell Wall What does Yeast Cell Wall (YCW) do?
Yeast cell wall is known to help: • Stimulate gut-associated immune function: YCW stimulates immune cells in the gut at the receptor level • Pathogen binding: YCW blocks attachment of bacterial pilli or fimbriae to intestinal epithelial cells as well as limiting afimbrial adhesions, preventing colonization by pathogenic bacteria • Directly alter intestinal morphology: YCW stimulates increased crypt depth resulting in longer intestinal villi to increase absorptive surface area and improve overall gut health. This may be of benefit, especially in young, rapidly-growing animals
What are the components of yeast cell wall?
Yeast cell wall comprises between 15-25% of the dry cell mass of a yeast (Saccharomyces cerevisiae) cell.
Mannoproteins (40%)
β
(1,6) glucans (8-10%) Soluble Component
β
(1,3) glucans (50%) Insoluble Component
Chitin (2%) Plasma
Outer cell wall
Inner cell wall
membrane
What pathogens might they help with?
YCW has been shown to help with many different pathogenic species such as Salmonella, E. coli, Clostridia, etc. to name a few but this will be dependent on strain of yeast as well as how it was manufactured.
What are the feeding recommendations?
Feeding Rates
Safmannan®/Safmune®
Adult Cow (beef & dairy)
2.0 g/hd/day
Calf/Heifer
2.2 g/hd/day
Can yeast cell wall be over fed?
Yes, feeding recommendations provided by manufacturers should be based on yeast strain and YCW purity of their product to avoid over-stimulation of the immune system.
How does Phibro yeast cell wall compare to other YCW products?
The key differentiating factor of our offering is the consistency of the product with limited batch to batch variation in glucan/ mannan levels and other quality measures. Phibro YCW products are manufactured in a consistent, high quality manner and supported by scholarly research. Therefore, our products elicit a more consistent response within the animal, based on application rate and proven performance.
FAQs Yeast Cell Wall Consistency of Phibro YCW Offering
Variability in Competitor YCW Offering
60 50
30
Mannans
20
Glucans
%
%
40
Sum
10 0 1
2
3
Phileo (Lesaffre)
4
5
6
7
8
45 40 35 30 25 20 15 10 5 0
Glucans Sum
1
9 10 11 12 13 14 15
Samples
Mannans
Phileo (Lesaffre)
2
3
4
5
6
Samples
Can yeast cell wall be used in milk replacers and liquid feeds?
Yes, they are water dispersible, which makes it compatible for use in calf milk replacers and other liquid feed applications.
Does the source of the yeast matter (bakers vs. brewers)?
Yes. Different strains of Saccharomyces cerevisiae are chosen for their ability to make carbon dioxide or alcohol and are thus used in baking, brewing or ethanol production, respectively. Similarly, yeast for animal feed usage is specifically selected for its ability to survive in harsh conditions of the gastrointestinal tract while regulating a balanced microbiome in the rumen and increasing feed digestibility. Live yeast or yeast cell wall made from baker’s yeast have been specially selected for feed application and have been fermented for that purpose. Brewer’s YCW is made from the spent, by-product of beer fermentation. Compared to active feed yeast, the brewer’s yeast contains few live cells. Also, baker’s yeast typically has a higher and more consistent glucan/mannan content than brewer’s yeast.
How do you know if a yeast cell wall product is high quality?
Monitoring parameters such as protein, moisture, glucan/mannan content provides a clear assessment of yeast growth and subsequent separation of the yeast cell wall.
Can Phibro provide me a Certificate of Analysis (COA) for glucans and mannans on their yeast cell wall product?
Phibro guarantees the minimum glucan and mannan levels for both its yeast cell wall product offerings (Safmannan and Safmune). The assay of glucans and mannans on every single batch is time consuming and costly, making it cost prohibitive. However, we regularly monitor glucan and mannan concentration to ensure consistent product quality.
YT010615 © 2015 Phibro Animal Health Corporation. BioSaf, Safmannan, Safmune and Procreatin-7 are registered trademarks owned by or licensed to Phibro Animal Health Corporation or its affiliates.
FAQs Live Yeast
How is live yeast defined as a feed additive?
Live yeast is active dry yeast (ADY) that must contain no less than 15 billion live cells/gram (15B CFU/gram) of live yeast count.
How does live yeast work in animals?
Specific strains of live S. cerevisiae have demonstrated their ability to scavenge ruminal oxygen. Live yeast consumes oxygen entering the rumen with feed and mastication, lowering redox potential and enhances the conversion of lactic acid to propionic acid. Live yeast also helps metabolize glucose (making it less available for fermentative bacteria), stimulates metabolism of lactate, stabilizes rumen pH and helps prevent acidosis. In addition, research indicates it increases the total number of beneficial bacteria in the rumen.
Can live yeast be pelleted?
Since pelleting conditions favor higher temperature, protected or coated yeast such as BioSaf® Sc 47 HR+, are specially designed to tolerate temperatures as high as 198°F (92C). This is a 32% increase in heat resistance over Procreatin-7® (P7), a standard (unprotected) live yeast, making it ideal for pelleted feed. P7 is thermostable up to 150° F (65.5C) with optimum levels of surviving live yeast and is an excellent choice for non-pelleted feed.
How stable is live yeast and Yeast Cell Wall (YCW) in a commodity shed with moisture and other environmental elements?
Live yeast is susceptible to moisture and environmental conditions. Stability is dependent on yeast strain, how the live yeast is manufactured, if it is protected and how it’s packaged. Yeast cell wall is stable under a variety of environmental conditions.
Would there be a benefit in feeding both live yeast and YCW?
Yes, increased benefits have been seen when a combination is used. The benefits seen are dependent on species, production stage, and its intended use. Live yeast helps promote: • Optimum rumen fermentation • Stabilization of rumen pH (lower risk of acidosis) • An increase in Dry Matter Intake • Fiber digestion to increase Milk Fat YCW may be fed to help: • Stimulate immune function • Protect against pathogens • Improve growth of young animals Live yeast and YCW are different but complementary for the overall benefit of animal health and performance.
What groups of animals on my farm would benefit from live yeast and YCW products?
All animals would be expected to benefit from using a yeast based product. The returns would be dependent on intended use, ration make up and environmental conditions.
What research do you have vs. competitive products?
Phibro live yeast and YCW products have been tested against competitive products and have shown advantages over other yeast products. Phibro has a system in place to maintain the primary strain of yeast to ensure each harvested batch is a pure, single-strain. Our highly controlled manufacturing process ensures the consistency of products from lot to lot.
FAQs Live Yeast Will live yeast be alive when it gets to the animal?
Live yeasts are viable, meaning they are metabolically active in the animal. For ruminants, live yeast are active in the rumen, however, a portion escapes the rumen and is active in the gastrointestinal tract similar to non-ruminant animals. However, the rate/amount in the lower gastrointestinal tract will be dependent on the ration provided to the animal.
Do live yeast and YCW work with ionophores?
Yes, live yeast and yeast cell walls both work in synergy with ionophores and are commonly used in practice together.
What is the Feeding Rate for live yeast?
BioSaf Sc47 HR+ Feeding Rate
BioSaf Sc47 HR+
Ration
GRAMS/HD/DAY
Adult Cow
5
Calf/Heifer
5
Procreatin-7 (P7) Feeding Rate
Procreatin-7 (P7)
Ration
GRAMS/HD/DAY
Adult Cow
4
Calf/Heifer
4
Does P7 survive mineral mixes and acids?
Tests done to check stability of P7 in mineral premix showed that levels remained consistent over the 8 week test period. Also, P7 tested in commercial dairy feed, in the presence of organic acids, remained stable for 6 weeks.
Will live yeast help with milk components?
Feeding live yeast, such as P7 or BioSaf Sc47 HR+, will assist with improving milk components, caused by rumen dysfunction. An example of this is when wild yeast has suppressed Milk Fat.
Yeast is yeast, isn’t it?
Not all yeasts are the same. The most common type of yeast used in animal agriculture is Saccharomyces cerevisiae. Strains of S. cerevisiae are selected for various applications: alcohol production, wine flavor production, ethanol production, high sugar bread applications, yeast extract yield and animal bacterial challenges, just to name a few. Different strains of yeast have different glucan/mannan content and helical structures, which can change their biological activity. Yeast manufacturing methods can also alter its biological activity.
Is there published research on yeast products?
We have several published articles in a wide variety of scientific journals. These are available on request.
Why would I need to add yeast to my rations if I am balancing my diets with adequate amounts of fiber? Yeast may be beneficial in digesting fiber, making it more available to the animal. Specific live yeasts have the ability to scavenge oxygen and help prevent the accumulation of lactate, which helps stabilize the rumen pH and reduce rumen acidosis. Live yeast may help modify the rumen microflora, which increases the fibrolytic bacteria (Fibrobacter and Ruminococcus) and lactate utilizing bacteria (Megasphera and Selenomonas), preventing the accumulation of lactate and allowing for better fiber digestion.
FAQs Yeast Cell Wall What does Yeast Cell Wall (YCW) do?
Yeast cell wall is known to help: • Stimulate gut-associated immune function: YCW stimulates immune cells in the gut at the receptor level • Pathogen binding: YCW blocks attachment of bacterial pilli or fimbriae to intestinal epithelial cells as well as limiting afimbrial adhesions, preventing colonization by pathogenic bacteria • Directly alter intestinal morphology: YCW stimulates increased crypt depth resulting in longer intestinal villi to increase absorptive surface area and improve overall gut health. This may be of benefit, especially in young, rapidly-growing animals
What are the components of yeast cell wall?
Yeast cell wall comprises between 15-25% of the dry cell mass of a yeast (Saccharomyces cerevisiae) cell.
Mannoproteins (40%)
β
(1,6) glucans (8-10%) Soluble Component
β
(1,3) glucans (50%) Insoluble Component
Chitin (2%) Plasma
Outer cell wall
Inner cell wall
membrane
What pathogens might they help with?
YCW has been shown to help with many different pathogenic species such as Salmonella, E. coli, Clostridia, etc. to name a few but this will be dependent on strain of yeast as well as how it was manufactured.
What are the feeding recommendations?
Feeding Rates
Safmannan®/Safmune®
Adult Cow (beef & dairy)
2.0 g/hd/day
Calf/Heifer
2.2 g/hd/day
Can yeast cell wall be over fed?
Yes, feeding recommendations provided by manufacturers should be based on yeast strain and YCW purity of their product to avoid over-stimulation of the immune system.
How does Phibro yeast cell wall compare to other YCW products?
The key differentiating factor of our offering is the consistency of the product with limited batch to batch variation in glucan/ mannan levels and other quality measures. Phibro YCW products are manufactured in a consistent, high quality manner and supported by scholarly research. Therefore, our products elicit a more consistent response within the animal, based on application rate and proven performance.
FAQs Yeast Cell Wall Consistency of Phibro YCW Offering
Variability in Competitor YCW Offering
60 50
30
Mannans
20
Glucans
%
%
40
Sum
10 0 1
2
3
Phileo (Lesaffre)
4
5
6
7
8
45 40 35 30 25 20 15 10 5 0
Glucans Sum
1
9 10 11 12 13 14 15
Samples
Mannans
Phileo (Lesaffre)
2
3
4
5
6
Samples
Can yeast cell wall be used in milk replacers and liquid feeds?
Yes, they are water dispersible, which makes it compatible for use in calf milk replacers and other liquid feed applications.
Does the source of the yeast matter (bakers vs. brewers)?
Yes. Different strains of Saccharomyces cerevisiae are chosen for their ability to make carbon dioxide or alcohol and are thus used in baking, brewing or ethanol production, respectively. Similarly, yeast for animal feed usage is specifically selected for its ability to survive in harsh conditions of the gastrointestinal tract while regulating a balanced microbiome in the rumen and increasing feed digestibility. Live yeast or yeast cell wall made from baker’s yeast have been specially selected for feed application and have been fermented for that purpose. Brewer’s YCW is made from the spent, by-product of beer fermentation. Compared to active feed yeast, the brewer’s yeast contains few live cells. Also, baker’s yeast typically has a higher and more consistent glucan/mannan content than brewer’s yeast.
How do you know if a yeast cell wall product is high quality?
Monitoring parameters such as protein, moisture, glucan/mannan content provides a clear assessment of yeast growth and subsequent separation of the yeast cell wall.
Can Phibro provide me a Certificate of Analysis (COA) for glucans and mannans on their yeast cell wall product?
Phibro guarantees the minimum glucan and mannan levels for both its yeast cell wall product offerings (Safmannan and Safmune). The assay of glucans and mannans on every single batch is time consuming and costly, making it cost prohibitive. However, we regularly monitor glucan and mannan concentration to ensure consistent product quality.
YT010615 © 2015 Phibro Animal Health Corporation. BioSaf, Safmannan, Safmune and Procreatin-7 are registered trademarks owned by or licensed to Phibro Animal Health Corporation or its affiliates.
