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Lyn SHIP1 Paper Figures_29042016_final_SM_MH.pptx
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Differen'al Lyn-‐dependence of the SHIP1-‐deficient mast cell phenotype
Suppl. Figure 7 (Fig. 4B)
A
qPCR IkBa V187x 4T_4
qPCR IkBa V136ax 4T_2 DNP20 100
60 40 20 0
con Ag
wt
con Ag
Lyn-/- SHIP1-/-
50 15 10 5 0
con Ag
dko
con Ag
wt
con Ag
con Ag
Lyn-/- SHIP1-/-
30 20 10 0
con Ag
dko
con Ag
wt
con Ag
con Ag
Lyn-/- SHIP1-/-
con Ag
dko
qPCR A20 V136ax 4T_2 DNP20
15 10 5 0
con Ag
wt
con Ag
con Ag
Lyn-/- SHIP1-/-
con Ag
dko
Nunes de Miranda et al. 2016
100
Tnfaip3 expression (rel. to wt con)
20
Tnfaip3 expression (rel. to wt con)
Tnfaip3 expression (rel. to wt con)
B
con Ag
40
Nfkbia expression (rel. to wt con)
Nfkbia expression (rel. to wt con)
Nfkbia expression (rel. to wt con)
80
50 30 20 10 0
con Ag
wt
con Ag
con Ag
Lyn-/- SHIP1-/-
con Ag
dko
80 40 15 10 5 0
con Ag
wt
con Ag
con Ag
Lyn-/- SHIP1-/-
con Ag
dko
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