Polymeric Framboidal Nanoparticles Loaded with a Carbon Monoxide ...
Supporting Information
Polymeric Framboidal Nanoparticles Loaded with a Carbon Monoxide Donor via Phenylboronic Acid-Catechol Complexation André J. van der Vlies†,‡, Ryosuke Inubushi‡, Hiroshi Uyama‡ and Urara Hasegawa*,‡,§
†
Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita,
Osaka 565-0871, Japan. ‡
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka,
Suita, Osaka 565-0871, Japan. §
Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University, 2-1
Yamadaoka, Suita, Osaka 565-0871, Japan.
* E-mail: [email protected]
Table of Contents Page S2:
Figure S1. ATR-IR spectra of CORM-3 and CO-DOPA. Figure S2. TEM image of the PBANPs.
Page S3:
Figure S3. Experimental setup for the CO release measurements. Figure S4. CO release from CORM-3 in the presence of cysteine.
Page S4:
Scheme S1. The different CORM-3 species formed in aqueous solutions at different pH.
S1
(a)
(b)
2300
2200
2100 2000 1900 Wavenumber [cm-1]
1800
Figure S1. ATR-IR spectra of (a) CORM-3 and (b) CO-DOPA.
Figure S2. TEM image of PBANPs negatively stained with 0.5 wt% Preyssler-type potassium phosphotungstate solution. Scale bar: 200 nm.
S2
Cysteine solution
CO detector
CO donor solution in a test tube Glass beads
Figure S3. Experimental setup for the CO release measurement.
Released CO per CO donor
0.12 0.1
10 mM
0.08 0.06 0.04 1 mM
0.02
0
0.1 mM
-0.02 0
60
120
180
240
Time [min]
Figure S4. CO release from CORM-3 in the presence of different cysteine concentrations.
S3
Scheme S1. The species formed in aqueous solution at different pH (Johnson et al. Dalton Transactions 2007, 15, 1500)
S4
Polymeric Framboidal Nanoparticles Loaded with a Carbon Monoxide Donor via Phenylboronic Acid-Catechol Complexation André J. van der Vlies†,‡, Ryosuke Inubushi‡, Hiroshi Uyama‡ and Urara Hasegawa*,‡,§
†
Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita,
Osaka 565-0871, Japan. ‡
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka,
Suita, Osaka 565-0871, Japan. §
Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University, 2-1
Yamadaoka, Suita, Osaka 565-0871, Japan.
* E-mail: [email protected]
Table of Contents Page S2:
Figure S1. ATR-IR spectra of CORM-3 and CO-DOPA. Figure S2. TEM image of the PBANPs.
Page S3:
Figure S3. Experimental setup for the CO release measurements. Figure S4. CO release from CORM-3 in the presence of cysteine.
Page S4:
Scheme S1. The different CORM-3 species formed in aqueous solutions at different pH.
S1
(a)
(b)
2300
2200
2100 2000 1900 Wavenumber [cm-1]
1800
Figure S1. ATR-IR spectra of (a) CORM-3 and (b) CO-DOPA.
Figure S2. TEM image of PBANPs negatively stained with 0.5 wt% Preyssler-type potassium phosphotungstate solution. Scale bar: 200 nm.
S2
Cysteine solution
CO detector
CO donor solution in a test tube Glass beads
Figure S3. Experimental setup for the CO release measurement.
Released CO per CO donor
0.12 0.1
10 mM
0.08 0.06 0.04 1 mM
0.02
0
0.1 mM
-0.02 0
60
120
180
240
Time [min]
Figure S4. CO release from CORM-3 in the presence of different cysteine concentrations.
S3
Scheme S1. The species formed in aqueous solution at different pH (Johnson et al. Dalton Transactions 2007, 15, 1500)
S4
