UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes Angela M. Farrell,*,† Yoshikazu Uchida,*,† M. Marek Nagiec,§ Ian R. Harris,*,† Robert C. Dickson,§ Peter M. Elias,*,† and Walter M. Holleran1,*,† Dermatology Service,* Department of Veterans Affairs Medical Center, San Francisco, CA 94121; and Department of Dermatology,† School of Medicine, University of California, San Francisco, CA 94121; and Department of Biochemistry and The Lucille P. Markey Cancer Center,§ University of Kentucky Medical Center, Lexington, KY
Supplementary key words barrier • ceramides • epidermis • keratinocytes • skin • sphingolipids • sphingosine • serine palmitoyltransferase • UVB
Ceramides, or acyl-sphingosines, are widely recognized as critical lipid species in the structure and function of the
permeability barrier of mammalian epidermis, representing