R edefi n in g R esearch

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Redefining Research

The Likarda team is very responsive to our needs. Tests are conducted and results are received on time and on budget. NOWsystem, Inc. receives OUTSTANDING VALUE FOR OUR RESEARCH INVESTMENT WITH LIKARDA.

Janice King • Dale Winetroub NOWsystem, Inc

A NEW DIMENS I ON IN DRUG DI S C OVERY LikardaBio supports pharmaceutical and therapeutic development companies by providing consultative research and analytical services from early stage drug discovery through lead compound optimization.

Research, Redefined Although LikardaBio performs many of the same functions of a traditional Contract Research Organization, we don’t consider ourselves a conventional CRO. With an uncommon approach to drug discovery, LikardaBio redefines the boundaries of research, using collaborative, consultative and customized methods. To perform the research our clients need to bring their products to market, we must understand their objectives. By designing an individualized research plan that meets those objectives, LikardaBio goes beyond just delivering data. Our clients enjoy a long-term analytical partnership that is unique in the world of outsourced contracts. What results is more intelligent science, enhanced data interpretation, assistance writing grants, publishing papers and abstracts, and other customized needs tailored to your specific goals.

A Multifaceted View Using our proprietary 3D screening approach, we have tested different diabetes and cancer drugs with known effects in humans using the conventional pharmaceutical approach and our 3D cell cluster. In each case our 3D approach results better mimicked how the drugs work in humans. Our clients can better predict responses to drug treatments with our process compared to conventional cell culture. We partner with both animal and human health companies to screen drug candidates in a species- and organ-specific manner.

Cell Number (Percent of Baseline)

SIDE-BY-SIDE COMPARISONS OF CLIENT’S PRODUCT VS. COMPETITIVE PRODUCTS

TOXICITY SCREENING; 3D TISSUES

WHOLE-ANIMAL IN VIVO STUDIES (CLIENT-OWNED DOGS)

Compound Dose (mg/mL)

Consultative and Analytical Services Likarda provides support for all phases of product development from early discovery through pre-clinical animal studies, including: • Toxicology

• Pharmacodynamics Studies

• Metabolism

• Other Cell-Based Assays

• Cell Health Assays

• Pre-Clinical Animal Studies

We also provide: • Review and interpretation of all study-related data • IND-enabling recommendations and studies • Preparation of peer-reviewed and expert opinion publications • Review of materials for brochures or collateral materials • Assistance or presentation of oral presentations for business or science audiences • Review and prepare materials for patents and regulatory agencies • Expedited services available (Rapid turnaround times)

Areas of Focus Likarda provides human and veterinary drug discovery and development services to: • Pharmaceutical • Nutraceutical • Supplements • Herbal Products • Cosmetics and Hygiene • Other Healthcare Products

The Leader in Regenerative Medicine Founded by entrepreneurs disguised as scientists at the University of Kansas, Likarda is an exciting new biotech company bringing to market cutting-edge technologies that improve healthcare outcomes and lower costs for pets and people alike. Likarda utilizes a proprietary cell culture system to create threedimensional cell clusters, or miniaturized organs, having applications in markets from drug discovery and development to cell-based transplantation and regenerative medicine. Because Likarda’s technologies span across animal and human health, this next generation company is already becoming a pioneer for future generations of translational medicine.

[email protected] • 913.945.8241

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