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RECENT TRENDS IN INCIDENCE, GEOGRAPHICAL DISTRIBUTION AND SURVIVAL FROM CORPUS UTERI CANCER IN WALES: 1985-2012 Ganiy Opeyemi Abdulrahman, Jnr Women’s Services, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom
Introduction Corpus uteri cancer is the sixth most common cancer in women across the world with a higher prevalence in the developed countries.1 In 2008, approximately 74000 women died of corpus uteri cancer worldwide, representing 1% of all cancer deaths.2
Results A total of 9063 cases of uterine cancer were registered with the Welsh cancer registry from 1985 to 2012 The age-standardised incidence rate of uterine cancer was 16.3 per 100000 population over the entire study period
In the United States of America, it is estimated that there will be almost 53000 new cases of endometrial cancer in 2014 with a corresponding 8590 deaths.3 In Europe, age-standardised incidence rate ranges from 10 to 39 per 100000 population.4 There is no previous study that has addressed the trends of corpus uteri cancer specifically in Wales. The aim of this study is to provide an up-to-date analysis of time trends in incidence, geographical distribution, survival and mortality from corpus uteri cancer in Wales using data from the national cancer registry for Wales.
Methods Cases of corpus uteri cancer registered between 1985 and 2012 were identified from the Welsh Cancer Intelligence and Surveillance Unit (WCISU). Age-standardised rates were determined using the European standard population.
Time trends in incidence rates of corpus uteri cancer in Wales, 1985-2012 The age group with the highest incidence of corpus uteri cancer is 60-74 years Over the study period, the average annual percentage increase was 2.68% per annum One-year and five-year relative survival improved over the study period.
A Poisson regression model was fitted to assess temporal trends and rate ratios (RR) and 95% confidence intervals (CI) were determined and compared in relation to age, geographical distribution and mortality across the study period.
All the 22 regions in Wales, except Gwynedd, recorded an increase in the incidence of uterine cancer over the study period. Local authority (Region) Total
EASR
AAPC
Anglesey Blaenau Gwent Bridgend Caerphilly Cardiff Carmarthenshire Ceredigion Conwy Denbighshire Flintshire Gwynedd Merthyr Tydfil Monmouthshire Neath & Port Talbot
248 237 416 460 716 644 221 406 301 403 407 181 285 470
17.5 17.8 17.2 15.3 14.4 18.1 15.9 15.5 15.0 15.5 16.5 17.7 15.5 17.7
+3.57 +2.10 +2.86 +3.97 +3.00 +2.94 +2.86 +1.43 +3.30 +3.20 0.00 +1.26 +4.68 +0.31
Newport Pembrokeshire Powys Rhondda Cynon Taff
374 384 457 748
15.2 15.8 17.6 18.2
+4.04 +3.36 +3.78 +1.06
Swansea Torfaen Vale of Glamorgan
765 279 317
17.4 16.9 13.9
+3.50 +2.38 +2.91
Wrexham
342
14.7
+1.88
Actual number of cases of corpus uteri cancer, European age-standardised rates (EASR) per 100000 population and average annual percentage change (AAPC) for local authority areas in Wales over the study period, 1985-2012
The data were analysed using IBM SPSS Statistics 20.
Mortality rates declined from 2.4 per 100000 population in 1985 until about 1999 when it was 1.7 per 100000 population, and then increased to 3.3 per 100000 population in 2012.
The level of statistical significance at which null hypothesis was rejected was chosen as 0.05.
One-year and five-year relative survival from corpus uteri cancer in Wales
Conclusions After a fairly steady rate in the 1980s and 1990s, the incidence of uterine cancer has increased significantly in the last 10 years Increasing incidence in risk factors such as diabetes and obesity may be contributory to this recent increase in incidence Corpus uteri cancer is commonest among the age group 60-74 years There has been a considerable improvement in both one-year and five-year relative survival over the last three decades There was an initial decline in mortality from corpus uteri cancer but there has been an increase in mortality in recent years, possibly corresponding to an increase in incidence in the last decade
References 1.Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61(2): 69-90 2.Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127(12): 2893-917 3.The Surveillance, Epidemiology, and End Results (SEER). http://seer.cancer.gov/statfacts/html/corp.html [Accessed June 2016] 4.EUCAN. http://eco.iarc.fr/eucan/CancerOne.aspx?Cancer=26&Gender=2 [Accessed 8th June 2016]
Mortality rates of corpus uteri cancer in Wales, 1985-2012
www.postersession.com
Introduction Corpus uteri cancer is the sixth most common cancer in women across the world with a higher prevalence in the developed countries.1 In 2008, approximately 74000 women died of corpus uteri cancer worldwide, representing 1% of all cancer deaths.2
Results A total of 9063 cases of uterine cancer were registered with the Welsh cancer registry from 1985 to 2012 The age-standardised incidence rate of uterine cancer was 16.3 per 100000 population over the entire study period
In the United States of America, it is estimated that there will be almost 53000 new cases of endometrial cancer in 2014 with a corresponding 8590 deaths.3 In Europe, age-standardised incidence rate ranges from 10 to 39 per 100000 population.4 There is no previous study that has addressed the trends of corpus uteri cancer specifically in Wales. The aim of this study is to provide an up-to-date analysis of time trends in incidence, geographical distribution, survival and mortality from corpus uteri cancer in Wales using data from the national cancer registry for Wales.
Methods Cases of corpus uteri cancer registered between 1985 and 2012 were identified from the Welsh Cancer Intelligence and Surveillance Unit (WCISU). Age-standardised rates were determined using the European standard population.
Time trends in incidence rates of corpus uteri cancer in Wales, 1985-2012 The age group with the highest incidence of corpus uteri cancer is 60-74 years Over the study period, the average annual percentage increase was 2.68% per annum One-year and five-year relative survival improved over the study period.
A Poisson regression model was fitted to assess temporal trends and rate ratios (RR) and 95% confidence intervals (CI) were determined and compared in relation to age, geographical distribution and mortality across the study period.
All the 22 regions in Wales, except Gwynedd, recorded an increase in the incidence of uterine cancer over the study period. Local authority (Region) Total
EASR
AAPC
Anglesey Blaenau Gwent Bridgend Caerphilly Cardiff Carmarthenshire Ceredigion Conwy Denbighshire Flintshire Gwynedd Merthyr Tydfil Monmouthshire Neath & Port Talbot
248 237 416 460 716 644 221 406 301 403 407 181 285 470
17.5 17.8 17.2 15.3 14.4 18.1 15.9 15.5 15.0 15.5 16.5 17.7 15.5 17.7
+3.57 +2.10 +2.86 +3.97 +3.00 +2.94 +2.86 +1.43 +3.30 +3.20 0.00 +1.26 +4.68 +0.31
Newport Pembrokeshire Powys Rhondda Cynon Taff
374 384 457 748
15.2 15.8 17.6 18.2
+4.04 +3.36 +3.78 +1.06
Swansea Torfaen Vale of Glamorgan
765 279 317
17.4 16.9 13.9
+3.50 +2.38 +2.91
Wrexham
342
14.7
+1.88
Actual number of cases of corpus uteri cancer, European age-standardised rates (EASR) per 100000 population and average annual percentage change (AAPC) for local authority areas in Wales over the study period, 1985-2012
The data were analysed using IBM SPSS Statistics 20.
Mortality rates declined from 2.4 per 100000 population in 1985 until about 1999 when it was 1.7 per 100000 population, and then increased to 3.3 per 100000 population in 2012.
The level of statistical significance at which null hypothesis was rejected was chosen as 0.05.
One-year and five-year relative survival from corpus uteri cancer in Wales
Conclusions After a fairly steady rate in the 1980s and 1990s, the incidence of uterine cancer has increased significantly in the last 10 years Increasing incidence in risk factors such as diabetes and obesity may be contributory to this recent increase in incidence Corpus uteri cancer is commonest among the age group 60-74 years There has been a considerable improvement in both one-year and five-year relative survival over the last three decades There was an initial decline in mortality from corpus uteri cancer but there has been an increase in mortality in recent years, possibly corresponding to an increase in incidence in the last decade
References 1.Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61(2): 69-90 2.Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127(12): 2893-917 3.The Surveillance, Epidemiology, and End Results (SEER). http://seer.cancer.gov/statfacts/html/corp.html [Accessed June 2016] 4.EUCAN. http://eco.iarc.fr/eucan/CancerOne.aspx?Cancer=26&Gender=2 [Accessed 8th June 2016]
Mortality rates of corpus uteri cancer in Wales, 1985-2012
www.postersession.com
